New York Giants interim head coach Mike Kafka confirmed on Wednesday that veteran Jameis Winston will be the starting quarterback on Sunday when the team takes on the visiting Green Bay Packers in Week 11 at MetLife Stadium. Rookie Jaxson Dart (concussion) is in the league's concussion protocol after injuring his head in the Week 10 loss to the Chicago Bears and will not play this weekend. It will be Winston, not Russell Wilson, starting under center this weekend with Dart sidelined. Tight ends coach Tim Kelly will be the offensive coordinator after the Giants fired head coach Brian Daboll earlier this week. Sunday will be Winston's first action of the year after he threw for 2,121 yards, 13 touchdowns, and 12 interceptions in 12 games (seven starts) for the Browns in 2024. Expect aggressive downfield passing with lots of sacks and turnovers for the Giants' offense this week, making the Packers' defensive unit a top fantasy option.

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Arizona Cardinals wide receiver Zay Jones (Achilles) tore his Achilles in last week's loss to the Seattle Seahawks on Sunday and will miss the rest of the season, according to Adam Schefter of ESPN. Additionally, the Cardinals will be without top wideout Marvin Harrison Jr. "this week and possibly longer" after he underwent surgery for appendicitis. Arizona's receiving corps will be very thin for quarterback Jacoby Brissett on Sunday against the division-rival San Francisco 49ers. Tight end Trey McBride should be a target hog, with Michael Wilson and Greg Dortch stepping up as the top two receiving options in the passing attack. Jones, 30, wasn't really on the fantasy radar to begin with in 2025 in a struggling Cardinals offense. He will finish with just 12 catches for 183 yards and no touchdowns in his eight games played.

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Washington Commanders running back Chris Rodriguez Jr. (shoulder) will play in Madrid, Spain, on Sunday in Week 11 against the Miami Dolphins and will have a key role, according to Cameron Wolfe of NFL Network. Rodriguez, who exited the Week 10 blowout loss to the Detroit Lions early with a shoulder injury, put in a full practice on Wednesday and will be good to go this week. Before getting hurt on Sunday, the 25-year-old saw six carries for 16 yards and a touchdown. With rookie Jacory Croskey-Merritt struggling of late, the Commanders have been giving more work to Rodriguez and Jeremy McNichols out of the backfield. At the very least, Rodriguez will have some RB3/flex appeal in deeper fantasy leagues this weekend as Washington's preferred goal-line option in a plus matchup versus Miami.

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Updating previous reports, Tampa Bay Buccaneers head coach Todd Bowles said that running back Bucky Irving (foot, shoulder) was limited in the team's walkthrough practice on Wednesday, according to Brianna Dix of Buccaneers.com. It was initially reported that Irving was rehabbing on the side and wouldn't practice, but he actually took part in some of the walkthrough, giving him a chance to play in Week 11 on Sunday against the Buffalo Bills for the first time since Week 4. The 23-year-old has been battling a sprained foot and a shoulder subluxation, with the shoulder injury being the primary reason he hasn't played since late September. It's good news for Irving's fantasy managers, but it's too early to expect him to be a fantasy factor this weekend. Even if Irving gets cleared to play this weekend, we could see plenty of Rachaad White and Sean Tucker out of Tampa's backfield.

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Buffalo Bills head coach Sean McDermott said on Wednesday that he's excited about new practice-squad wide receiver Mecole Hardman, according to Joe Buscaglia of The Athletic. McDermott talked about Hardman's speed element and his positional versatility. The 27-year-old pass-catcher joined Buffalo's practice squad on Monday and could immediately join the team's 53-man active roster for a Week 11 meeting with the Tampa Bay Buccaneers this Sunday if top wideout Khalil Shakir (rib) is unable to play. Hardman was cut from the Green Bay Packers' practice squad in late September and hasn't played in a game this season. Last year, in 12 games with the Kansas City Chiefs, he caught 12 of 14 targets for 90 yards, adding five rushing attempts for 62 yards and a touchdown. Even if Shakir and Joshua Palmer (ankle, knee) are inactive in Week 11, Hardman will be a long shot for any kind of fantasy production if he makes his Bills debut.

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Buffalo Bills head coach Sean McDermott said that wide receiver Khalil Shakir (rib) will be limited in Wednesday's practice due to a rib injury, according to Joe Buscaglia of The Athletic. Tight end Dalton Kincaid (hamstring) isn't practicing on Wednesday and is considered week-to-week, so quarterback Josh Allen's top two targets could be missing in action this weekend versus the Tampa Bay Buccaneers. Shakir has a better shot at suiting up, but his status will be worth monitoring closely as Sunday approaches. He currently leads the Bills in catches (45), targets (58), and receiving yards (457) while finding the end zone three times. If both Shakir and Kincaid cannot play in Week 11, Keon Coleman would be Buffalo's top wideout, with Dawson Knox taking over primary TE pass-catching duties. Allen might be forced to use his legs more often against Tampa.

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Buffalo Bills tight end Dalton Kincaid (hamstring) will not practice on Wednesday, per Jak Skurski of The Buffalo News. Kincaid injured his hamstring in the Week 10 upset loss to the Miami Dolphins and is considered week-to-week. A DNP for the first practice of the week is a bad sign for Kincaid's chances of playing this Sunday against the Tampa Bay Buccaneers in Week 11. Fantasy managers who have been using Kincaid as their TE1 need to make sure they have a backup plan in place. In addition to Kincaid, Buffalo's top wideout, Khalil Shakir (rib), is nursing a rib injury that makes him questionable to play this week. If Kincaid cannot get the green light to face the Bucs, Dawson Knox would become a TE2 streamer for fantasy managers in need of help at the position. Kincaid currently ranks second on the Bills with 448 receiving yards and leads the team with four touchdown receptions.

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Arizona Cardinals head coach Jonathan Gannon did not give an update on running back Trey Benson (knee) on Wednesday, according to Theo Mackie of The Arizona Republic. Benson was eligible to return from Injured Reserve and play in Week 10, but that did not happen, and it remains unclear if he'll have his 21-day practice window opened this week. At the very least, it doesn't look likely that the 23-year-old second-year back will come off IR to play this Sunday against the division-rival San Francisco 49ers. The Cardinals also don't have an update on Bam Knight (ankle), who picked up an ankle injury in the Week 10 loss to the Seattle Seahawks. With Benson not expected to return this week and Knight's status up in the air, Emari Demercado could be Arizona's primary option in the backfield this weekend. Michael Carter would also see an uptick in touches if both Benson and Knight are ruled out.

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Arizona Cardinals head coach Jonathan Gannon did not have an injury update on running back Bam Knight (ankle) on Wednesday, according to Theo Mackie of The Arizona Republic. Knight, who has become the Cardinals' primary option in the backfield in recent weeks with Trey Benson (knee) on Injured Reserve, picked up an ankle injury in the fourth quarter of the Week 10 loss to the Seattle Seahawks. The 24-year-old only had 28 rushing yards on 10 carries in the blowout loss before leaving, adding one catch for five yards. Fantasy managers will want to check back on Knight's practice status on Wednesday. Benson has yet to resume practicing, so he feels unlikely to make his return this Sunday against the division-rival San Francisco 49ers. Fantasy managers in need of RB help may want to pick up Emari Demercado now in case Knight is unable to go this weekend.

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ESPN's Dan Graziano thinks that New England Patriots running back Rhamondre Stevenson (toe) will "reclaim his former roles as the Patriots' main between-the-tackles runner" when he's healthy. Stevenson injured his toe in the Week 8 win over the Cleveland Browns and has missed the last two games. The Pats entered the week with hope that he'd return for Thursday night's game against the division-rival New York Jets, but as of Tuesday night, "it looked as if that return would likely have to wait until Week 12." Rookie TreVeyon Henderson went over 100 rushing yards and scored two touchdowns in the Week 10 win over the Tampa Bay Buccaneers, but the Patriots "still trust the veteran Stevenson more in certain spots and would like to continue using both of them." It's not great news for Henderson's fantasy managers, but Graziano also adds that New England could look to incorporate the rookie more once Stevenson is back.

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ESPN's Adam Schefter reports that Arizona Cardinals wide receiver Marvin Harrison Jr. (appendix) underwent surgery for appendicitis and will be sidelined for "at least this week and possibly longer." It's a tough blow for the 23-year-old, who had recorded 10 catches for 129 yards and two touchdowns on 22 targets over the last two weeks. Harrison Jr. will now miss his team's Week 11 matchup against the San Francisco 49ers, and it appears there's no guarantee he'll be back in Week 12 to face the Jacksonville Jaguars. Without Harrison Jr. on the field, Arizona tight end Trey McBride could see an even larger target share. Additionally, Cardinals wideout Michael Wilson could be in line for significantly more looks from quarterback Jacoby Brissett. Wilson saw a season-high seven targets in Week 10 and may be in for another target spike in Week 11.

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In his team's first game following their Week 9 bye, Cleveland Browns wide receiver Jerry Jeudy hauled in six of 12 targets for 78 yards and a touchdown in Week 10 against the New York Jets. It's been an inconsistent season overall for the 26-year-old, who has recorded 28 catches for 335 yards and a score on 66 targets across nine games. However, Jeudy has now earned at least 12 targets in two out of his last four games played. If Week 10 was a sign of budding chemistry between Jeudy and Browns rookie quarterback Dillon Gabriel, the opportunity could be there for Jeudy to be a breakout player in fantasy over the second half of the season. Jeudy profiles as a low-end WR3/flex option heading into a Week 11 matchup against the Baltimore Ravens.

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NFL insider Ian Rapoport reported that the New York Giants have elevated Jameis Winston to the No. 2 quarterback on the depth chart and expect him to start Sunday in the event Jaxson Dart (concussion) doesn't clear the concussion protocol, per The Insiders. Winston was moved ahead of Russell Wilson, as interim coach Mike Kafka informed them. Additionally, ESPN's Adam Schefter reported that the Giants are expected to start quarterback Winston against the Green Bay Packers on Sunday, sources told Schefter and Jordan Raanan of ESPN on Wednesday. In a significant turn of events, both Schefter and Rapoport have reported that it's likely Winston gets the start against the Packers. He immediately raises the ceiling of the Giants' playmakers like Darius Slayton, Theo Johnson, and Wan'Dale Robinson, compared to what Russel Wilson can bring to the table at this point in his career. Winston is a bit of a wild card, but he will bring much more excitement to the team and Sunday's matchup. In his career, he has thrown for 24,225 yards, 154 touchdowns, and 111 interceptions. He can be started as a wild card in QB2 leagues once he is confirmed to be the starter.

Tampa Bay Buccaneers running back Bucky Irving (shoulder, foot) was spotted participating in the team's Wednesday morning walkthrough, according to Greg Auman of Fox Sports. Although he was never placed on Injured Reserve, Irving has missed five straight games for Tampa Bay due to shoulder and foot injuries. Irving's participation in a walkthrough does not necessarily mean he's on track to play in Week 11 against the Buffalo Bills, but it's at least a step in the right direction. Across the four games he's played in 2025, the 23-year-old has recorded 430 yards from scrimmage and two touchdowns on 90 total touches. Irving should eventually take over as the clear RB1 in Tampa Bay once he returns to the lineup. However, the team could re-integrate him slowly alongside running backs Rachaad White and Sean Tucker until Irving is fully healthy. Fantasy managers should check back throughout the week for updates on Irving's status heading into Sunday.

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New Orleans Saints quarterback Tyler Shough had a breakout performance in his first career win, completing 19 of 27 passes for 282 yards and two touchdowns in the 17-7 victory over the Panthers. Shough played with confidence throughout, connecting with Chris Olave on a 62-yard score in the second quarter to give the Saints the lead, and they never looked back. He later found Juwan Johnson for a 30-yard touchdown to seal the win. Shough had three completions over 25 yards, something the Saints had only achieved six times through Weeks 1-8 under Spencer Rattler. His deep-ball upside makes him a matchup-dependent streaming option, with Week 12 against the Falcons his next opportunity.

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Tampa Bay Buccaneers tight end Cade Otton had his best game of the 2025 season in Week 10, recording nine catches for 82 yards on 12 targets against the New England Patriots. After averaging 2.8 targets per game over the first four weeks of the season, Otton has averaged 7.4 targets per contest over his last five games. The 26-year-old appears to be one of the clear beneficiaries of injuries to Buccaneers wide receivers Mike Evans (collarbone) and Chris Godwin (leg). With Evans currently on Injured Reserve and Godwin trending towards missing his fifth straight game, Otton should continue to be a featured player in Tampa Bay's passing game. He profiles as a low-end starting fantasy tight end heading into a Week 11 matchup against the Buffalo Bills.

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Minnesota Vikings running back Aaron Jones Sr. has been limited to just five games played this season due to a hamstring injury that sidelined him from Week 3 to Week 7. However, the 30-year-old has been productive since returning to the lineup. Over his last two games, Jones Sr. has recorded 167 yards from scrimmage and a touchdown on 23 total touches. Perhaps most importantly, Jones Sr. appears to be re-emerging as Minnesota's lead back. In Week 10, Jones Sr. played 71% of the Vikings' offensive snaps, compared to just 25% for fellow running back Jordan Mason. Jones Sr. also saw a season-high six targets in Week 10. Heading into a favorable Week 11 matchup against the Chicago Bears, Jones Sr. profiles as a solid fantasy RB2.

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The Pittsburgh Steelers have activated quarterback Will Howard (hand) from Injured Reserve and waived running back Trey Sermon to make room for Howard on the 53-man roster. A sixth-round pick in the 2025 draft, Howard fractured his hand in training camp and was placed on Injured Reserve before the start of the regular season. In his senior season at Ohio State, Howard led the Buckeyes to a national championship and threw for 4,010 yards, 35 touchdowns, and 10 interceptions across 16 games. Howard appears likely to serve as the QB3 behind Aaron Rodgers and Mason Rudolph in Pittsburgh, at least for the time being. The 24-year-old has some deep-league dynasty appeal due to the uncertain long-term future of the quarterback position in Pittsburgh, but Howard is unlikely to factor in redraft fantasy leagues this season.

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Tampa Bay Buccaneers wide receiver Chris Godwin (fibula) is not expected to practice on Wednesday, according to the Tampa Bay Times' Rick Stroud. Godwin remains in "rehab mode," and early reports suggest he's trending toward a late-November or early-December return. The veteran wideout has appeared in just two games this season, contributing minimally as he continues to recover from the fractured fibula he suffered in 2024. In his absence, rookies Emeka Egbuka and Tez Johnson have stepped up as key targets in the passing game. The Buccaneers are expected to provide further updates on Godwin's progress later this month.

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New England Patriots rookie running back TreVeyon Henderson will look to build on his breakout performance heading into Week 11. Henderson dominated the backfield in Week 10, racking up 150 scrimmage yards and two touchdowns on 15 touches to help lead the Patriots past the Tampa Bay Buccaneers. Fantasy managers had been waiting for Henderson to get his opportunity, and he capitalized in a big way, playing 84% of the snaps after Rhamondre Stevenson (toe) was ruled out and Terrell Jennings (knee) exited early. With both backs still limited in practice ahead of Thursday night's matchup against the New York Jets, Henderson could be in line for a workhorse role and another big fantasy outing in Week 11.

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