San Francisco 49ers quarterback Mac Jones has been able to make the most of this starting opportunity while Brock Purdy (toe) is sidelined. On Sunday, Jones did everything he could to help his team win, but unfortunately it wasn't enough. He completed 33-of-39 passing attempts for 319 yards with three touchdowns and one interception in the loss to the Los Angeles Rams. Jones made some mistakes as well, but he also posted his third 300-plus yard passing game of the season. It's unclear if Purdy will be ready to start for the Week 11 matchup against the San Francisco 49ers. If not, Jones should be viewed as a streaming option for that one.

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Detroit Lions quarterback Jared Goff didn't seem to have any issues during Sunday's game against the Washington Commanders. This defense had absolutely no answers for Goff as he picked them apart all game. Goff completed 25-of-33 passing attempts for 320 yards with three touchdowns and zero interceptions in the win. The 31-year-old has now thrown for multiple touchdowns in five of his last six games. This marked only the second time this season that Goff has thrown for over 300 yards in a single game. He'll look to keep the fun times going against the Philadelphia Eagles next weekend.

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Arizona Cardinals tight end Trey McBride posted his best performance of the season during Sunday's game against the Seattle Seahawks. McBride carried a three-game touchdown-streak into this contest, which was in jeopardy until he scored mid-way through the third quarter. Overall, McBride finished with nine receptions on 15 targets for 127 yards and one score in the blowout loss. McBride has seen his fantasy value quickly rise with Jacoby Brissett under center. The Cardinals figure to ride with Brissett for the rest of the season, which is good news for McBride fantasy managers. He'll carry his now four-game touchdown-streak into the Week 11 matchup against the San Francisco 49ers.

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Los Angeles Rams quarterback Matthew Stafford completed 24 of his 36 pass attempts for 280 yards, four touchdowns, and zero interceptions during Sunday's Week 10 win over the San Francisco 49ers. The veteran quarterback continues to strengthen his MVP candidacy, playing turnover-free football while racking up passing touchdowns. He has now thrown for at least four touchdowns in each of his last three games, totaling 13 touchdowns and zero turnovers during that three-week span. He has a whopping 25 touchdowns and just two turnovers in 2025, keeping the Rams in the hunt for the top seed in the NFC. All the while, he has maintained QB1 value in fantasy football despite his lack of rushing upside. Managers should start him in all leagues ahead of next week's matchup against the Seattle Seahawks.

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Detroit Lions running back Jahmyr Gibbs had 15 carries for 142 rushing yards and two rushing touchdowns during Sunday's Week 10 win over the Washington Commanders. He also caught three of his four targets for an additional 30 receiving yards and one receiving touchdown. Just one week removed from a disappointing showing at home, Gibbs bounced back with a monstrous three-touchdown explosion on the road. This marked his largest fantasy points total of the 2025 season, vaulting him to the overall RB4 spot in PPR leagues. Managers should continue to deploy Gibbs as a high-end RB1 in fantasy football, including next week against the Philadelphia Eagles.

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Los Angeles Chargers running back Omarion Hampton (ankle) was not wearing a walking boot as he watched his teammates warm up ahead of Sunday's Week 10 contest against the Pittsburgh Steelers. The absence of a boot is a promising sign as Hampton inches closer to his return from injured reserve. The rookie has been sidelined since Week 5, leaving Kimani Vidal as the team's lead running back. Once Hampton is healthy enough to return, he should reclaim the every-down role that he occupied prior to his injury. Before he's activated, though, he'd need to be designated to return and log a few promising practice sessions. As soon as he gets back onto the field, he'll rank as a solid RB1 for fantasy football.

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San Francisco 49ers quarterback Brock Purdy (toe) will "have a chance" to play in next week's contest against the Arizona Cardinals, head coach Kyle Shanahan told the media. The 25-year-old has been sidelined for most of this season, playing just two of the Niners' 10 games so far. Mac Jones is playing above .500 in his absence, but he lost to the Rams on Sunday and now has six turnovers over his last four games. The return of Purdy should elevate the 49ers' offense while continuing to support strong fantasy outings from players like Jauan Jennings, George Kittle, and Christian McCaffrey. Meanwhile, Purdy himself should rank as a low-end QB1 in fantasy football.

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Los Angeles Rams wide receiver Davante Adams (oblique) suffered an oblique injury during Sunday's Week 10 win over the San Francisco 49ers, head coach Sean McVay told the media. The Rams are hopeful that Adams will be alright, and McVay believes Adams could have possibly returned to Sunday's game if the score had been closer. Overall, the team seems to be adopting a positive tone in regards to the injury that ended Adams' day early. It sounds like he has a good chance to play in Week 11 against the Seattle Seahawks, but fantasy managers should still check for updates on the Rams' injury reports from Wednesday through Friday. If confirmed as active next week, Adams would continue to operate as a WR1 in fantasy football.

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New Orleans Saints tight end Juwan Johnson caught all four of his targets for 92 yards and a touchdown during Sunday's Week 10 win over the Carolina Panthers. The highlight of Johnson's game was a 30-yard touchdown reception that extended New Orleans' lead to multiple possessions. It was a bit unclear how top receivers like Johnson and Chris Olave would perform in rookie quarterback Tyler Shough's second career start, but both pass catchers turned in big outings while strengthening their rapport with the Louisville product. Johnson has been a pleasant surprise in fantasy football this year, ranking as the overall TE6 in PPR leagues with 43 catches, 491 yards, and a trio of scores. He should continue to be started in all leagues on the other side of the Saints' Week 11 bye.

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Buffalo Bills quarterback Josh Allen completed 28 of his 40 pass attempts for 306 passing yards, two touchdowns, and one interception during Sunday's Week 10 loss against the Miami Dolphins. He also rushed for 31 yards, took three sacks, and lost a fumble. The loss and two turnovers are a major blemish on Allen's 2025 statistics, but he offered his fantasy managers some relief with two touchdowns and over 300 yards. For the most part, managers won't care whether the Bills win or lose, as long as their quarterback continues to post solid fantasy performances. Nevertheless, he'll look to clean things up ahead of Week 11 against the Tampa Bay Buccaneers. Allen should still be trusted as a strong QB1 in fantasy football.

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Arizona Cardinals running back Bam Knight (ankle) exited during the third quarter of Sunday's Week 10 contest against the Seattle Seahawks. He is officially listed as questionable to return, but it seems unlikely he gets back into the game since Arizona trails by multiple scores in the waning minutes. If Knight's day is indeed done, he finishes Week 10 with 10 carries for 28 rushing yards. He also converted four targets into just one catch for an additional five receiving yards. It was a relatively inefficient outing for the 24-year-old and could cost him some opportunities heading into Week 11 against the San Francisco 49ers. Emari Demercado, who has more than 180 scrimmage yards over the last two games, could poach some of Knight's volume. Demercado remains the most intriguing Arizona running back in fantasy football, ranking as an RB3/flex. Knight falls into the RB4 tier.

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Cleveland Browns head coach Kevin Stefanski said that "he's sticking with [quarterback] Dillon Gabriel and will continue to coach him up" ahead of Week 11 versus the Baltimore Ravens, according to Mary Kay Cabot of Cleveland.com. Gabriel completed 17 of 32 passes for 167 yards, two touchdowns, and zero interceptions during Sunday's loss to the New York Jets. He also showcased significant mobility late in the game, adding five rushing attempts for 54 rushing yards. The rookie had a decent day in terms of scoring, limiting turnovers, and running the ball, but he'll need to improve on his completion rate and total yardage. Nevertheless, Stefanski sees enough potential in the Oregon product to keep him involved in the first-team offense going forward. He'll rank as a low-end QB2 with the potential to rack up garbage-time points against the Baltimore Ravens in Week 11.

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Los Angeles Rams wide receiver Davante Adams (back) exited during the second half of Sunday's Week 10 contest against the San Francisco 49ers. He is officially listed as questionable to return, but it seems unlikely that he plays any more snaps with Los Angeles leading by multiple possessions in the waning minutes. If Adams' day is indeed done, he finishes with six catches, 77 yards, and a touchdown. The veteran receiver led the team in yards and was one of four players to haul in a touchdown pass from Matthew Stafford. He will continue to rank as a strong WR1 option in fantasy football ahead of next week's game against the Seattle Seahawks.

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Washington Commanders running back Chris Rodriguez Jr. (shoulder) exited during the second half of Sunday's Week 10 contest against the Detroit Lions. He is officially listed as questionable to return. At the time of his departure, he had six carries for 16 rushing yards and a touchdown, sharing work with Jacory Croskey-Merritt and Jeremy McNichols. As long as this backfield continues to operate out of a committee, all three backs will be tough to trust in fantasy football. Managers who roster any of the three running backs should stay tuned for updates on Rodriguez, as his status will impact the backfield split in Week 11 against the Miami Dolphins.

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Washington Commanders DT Daron Payne was ejected in the second quarter against the Detroit Lions in Week 10 after throwing a punch at WR Amon-Ra St. Brown.

Dynasty | Falcons receiver Drake London had six catches for 104 yards and a touchdown in Atlanta's week ten loss to the Colts. Dynasty Analysis: London is putting together a career year and clearly has something clicking with Michael Penix Jr. While the game results haven't been there very often for the Falcons, you can't blame London, who is pushing for top-5 receiver status in dynasty leagues at this point. The buying window on London has clearly closed.

Minnesota Vikings WR Adam Thielen caught two passes for 16 yards against the Baltimore Ravens in Week 10. He was targeted three times during the game.

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Tampa Bay Buccaneers wide receiver Emeka Egbuka bounced back in a big way during Sunday's game against the New England Patriots. He got the fun started early with a 21-yard touchdown grab on the Bucs opening drive. Egbuka continues to be a focal point on this Bucs offense that is extremely shorthanded. The rookie wideout hauled in six of his 13 targets for 115 yards and a score in the loss. It's unclear if the Bucs will get any reinforcements ahead of their Week 11 matchup against the Buffalo Bills. Regardless, Egbuka should remain a big factor in this offense going forward.

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Minnesota Vikings RB Aaron Jones rushed for 47 yards and one touchdown on nine carries against the Baltimore Ravens in Week 10. He also caught three passes for 22 yards during the game.

Fantasy Spin: Jones was dealing with injuries leading up to the game but received most of the carries in the running game and was able to reach the end zone. He will probably see a few more carries next week and can be at least a flex option in fantasy leagues.

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New Orleans Saints wide receiver Chris Olave was able to come up huge for his team during Sunday's game against the Carolina Panthers. His biggest play of the game was a 62-yard touchdown in the second quarter. Olave would finish his day by hauling in five of his eight targets for 104 yards and one score in the victory. It appears the fourth-year wideout is building solid chemistry with rookie quarterback Tyler Shough. This was a promising performance from Olave as fantasy managers are hopeful for more big games like this from Olave going forward. Sadly, fantasy managers will have to wait until Week 12 as the Saints head into a bye week.

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