Los Angeles Rams wide receiver Puka Nacua continues to be a spectacular fantasy option heading into Week 10 against the San Francisco 49ers. The 24-year-old has 61 catches for 711 receiving yards and three receiving touchdowns this year, ranking as the overall WR4 in PPR leagues -- and he would be in the running for WR1 if he hadn't missed a game and a half in October. Nacua should continue to be deployed in all fantasy leagues, and managers shouldn't give the decision a second thought. In his last outing against the Niners, the star receiver caught 10 passes for 85 yards and a touchdown. Meanwhile, San Francisco has surrendered the sixth-most receptions and eighth-most receiving yards to opposing wide receivers in 2025.

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Washington Commanders wide receiver Chris Moore has been thrust into a high snap share this season with Terry McLaurin (quadriceps) and Noah Brown (groin) both missing extended periods of time. Moore has operated as Washington's primary outside receiver in their absences and has led the team in snaps in two of the past three weeks. The 32-year-old hasn't been very productive despite running a high number of routes, catching eight of his 17 targets for 164 yards and a touchdown in eight games this season (four starts). The veteran will likely see a lot of playing time again in a favorable Week 10 against a Lions defense that has allowed the sixth most PPR points per game to opposing wide receivers. Moore hasn't fared as well in Marcus Mariota's starts compared to Jayden Daniels (elbow), posting just two receptions for 25 yards across Mariota's three starts. Moore is a desperation play only in deeper leagues on Sunday.

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Los Angeles Rams running back Blake Corum could be headed for reduced volume during Sunday's Week 10 matchup against the San Francisco 49ers. Corum, the Rams' backup to Kyren Williams, has been heavily involved over the last two weeks, touching the ball 26 times, but his increased workload was likely a direct product of the Rams taking large leads over the Jaguars and Saints. They're expected to play a much closer game against the Niners, leaving fewer opportunities for depth players like Corum to touch the ball. In fact, when the Rams and 49ers last played against each other in Week 5, Corum had just one touch on a season-low nine percent snap share. His recent efficiency (4.46 YPC last week) should earn him more than one touch this time around, but his double-digit touch totals from the last two weeks might be out of reach. He should continue to be left on fantasy benches as a mere handcuff behind Williams.

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Washington Commanders wide receiver Deebo Samuel Sr. has had a few down weeks after a hot start to the season. Samuel has posted just 12 catches for 67 yards on 17 targets to go with three carries for three yards over his past three games. The veteran missed Washington's Week 7 matchup in Dallas due to a heel injury, which could be impacting his performance. Samuel will be without second-year quarterback Jayden Daniels (elbow) for a few weeks, which will likely hurt Samuel's production a bit. In Marcus Mariota's three starts, Samuel has still been solid and leads the team in targets (15) and receptions (11), but is third in receiving yards (94) and has scored one touchdown. Samuel has a solid matchup in Week 10 against a Lions defense that has allowed the sixth most PPR points per game to opposing wide receivers. Samuel ranks as RotoBaller's WR21 in PPR leagues for Sunday.

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Arizona Cardinals wide receiver Marvin Harrison Jr. is coming off one of the best games of his career in Week 9's win over the Dallas Cowboys, catching seven of his 10 targets for 96 yards and a touchdown. The seven receptions marked a career high for Harrison, while the 96 yards were his most since Week 4 against the Seahawks. The second-year wideout has benefited from having Jacoby Brissett as the starting quarterback and should continue to see better fantasy days moving forward. The 23-year-old has totaled 31 catches for 492 yards and three touchdowns on 50 targets in eight games this season. Harrison has a tougher matchup against a good Seahawks defense, but he performed well against them earlier this year, and his value is on the rise after a strong Week 9 performance. Harrison is ranked as RotoBaller's WR11 in PPR leagues for Week 10.

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Atlanta Falcons running back Tyler Allgeier was a non-factor last week after the Falcons got down early, recording just two rushes for six yards. The 25-year-old now has 11 rushes for 30 yards and one touchdown in the team's last four losses, compared to 42 rushes for 159 yards and three touchdowns in their three wins. Unless the Falcons can keep Week 10's matchup close, Allgeier could be an afterthought again. Atlanta is a 6.5-point underdogversusthe Colts in Germany on Sunday, and with the fourth-year pro having basically no involvement in the passing game, he's a touchdown-dependent RB4/Flex play this week with very little upside and a near-zero floor.

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Los Angeles Rams running back Kyren Williams remains a must-start fantasy option in Week 10 against the San Francisco 49ers as he looks to build on a successful first half of the 2025 season. Williams has 586 rushing yards, 166 receiving yards, and six touchdowns so far, ranking as the overall RB13 in PPR leagues. On paper, a matchup against the 49ers could pose a challenge for running backs, as San Francisco ranks near the middle of the league in fantasy points allowed to the position. They've also surrendered the seventh-fewest rushing touchdowns to running backs. However, Williams didn't see that level of shutdown defense when the 49ers faced the Rams in Week 5. During that matchup, the 25-year-old had 14 carries, 65 rushing yards, eight catches, 66 receiving yards, and two receiving touchdowns. His 32.1 points (PPR) represented a season-high. Williams will look to repeat his success against a banged-up 49ers defense this week, and he should continue to be deployed as an RB1 in most leagues.

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Los Angeles Rams quarterback Matthew Stafford is having one of the best seasons of his career, and he remains a must-start fantasy quarterback in Week 10 against the San Francisco 49ers despite his limited rushing upside. Stafford now has 16 touchdowns and zero interceptions over his last five games, leading the Rams to a 6-2 start while supporting big fantasy performances from Puka Nacua, Davante Adams, and Kyren Williams. Stafford himself is the overall QB9 so far, and he's fourth in the MVP race with +500 odds. He has become matchup-proof this season and should be started against all opponents. With that said, a matchup against the San Francisco 49ers certainly doesn't hurt. The Niners have allowed the ninth-most fantasy points to opposing quarterbacks in 2025 and have forced just one interception. Stafford racked up 389 yards and three touchdowns when he faced the 49ers earlier this season.

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Arizona Cardinals running back Bam Knight has operated as the team's lead back over the past three games, recording 34 carries for 118 yards and a touchdown and adding six receptions (eight targets) for 47 yards. Knight has played 104 total snaps since Week 6, with the next closest Cardinals running back being Michael Carter at 57, but he didn't record a single snap in their Week 9 win over the Dallas Cowboys. The 25-year-old Knight was out-gained by Emari Demercado in that game, but saw a season high in snap share of 56.9% to Demercado's 40%. It looks like Arizona is trending toward becoming a split two-man backfield between Knight and Demercado, but nothing is set in stone. Head coach Jonathan Gannon has been tight-lipped about how they will distribute the running back touches week to week, but Knight should again be expected to lead Arizona's backfield on early downs in a tough Week 10 matchup against a Seahawks defense that is allowing a league-best 3.5 yards per carry.

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The Cleveland Browns activated wide receiver Cedric Tillman (hamstring) from Injured Reserve on Saturday, per Adam Schefter of ESPN. Tillman was able to practice in full every day this week and will make his return in Week 10 against the New York Jets after missing four weeks due to a hamstring injury. Tillman was productive over the first four games of the season, catching 11 of his 20 targets for 106 yards and two touchdowns. The 25-year-old wideout had a mini-breakout last season after the Browns traded away Amari Cooper, catching 24 of 40 targets for 302 yards and three touchdowns in a four-game span before his season was cut short due to a concussion. Cleveland's offensive environment is not as favorable this season with Dillon Gabriel at the helm, and while Tillman presents some upside, he shouldn't be in fantasy lineups for Week 10.

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Cleveland Browns running back Jerome Ford will come out of his bye to take on the New York Jets on the road in Week 10. Ford has been lightly used behind starter Quinshon Judkins this season, seeing just 21 carries and 21 receptions over eight games. The veteran running back draws a plus matchup in theory against the Jets, who are allowing the eighth-most fantasy points per game to running backs. That said, Ford is unlikely to see a large enough workload to rack up fantasy points against New York. He remains a solid bench stash as a handcuff, but should not be in fantasy lineups heading into Week 10.

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Cleveland Browns running back Dylan Sampson has shown skills in the passing attack this season, most recently hauling in five of his six targets for 29 yards in a Week 8 loss to the New England Patriots. Sampson will now take on the New York Jets on the road in Week 10 after enjoying his bye in Week 9. The Jets have struggled against the run this season, allowing the eighth-most fantasy points per game to running backs thus far. That being said, Sampson is tough to trust in fantasy as the Browns have been relying heavily on Quinshon Judkins in the rushing attack. Sampson will need to do his damage in the passing game to return fantasy value, something that is not a given in a game where the Browns are two-point road favorites against New York.

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Arizona Cardinals running back Emari Demercado led the team in rushing in their Week 9 win over the Dallas Cowboys, handling 14 carries for 79 yards. Demercado's role for Week 10, however, is still uncertain after head coach Jonathan Gannon has provided no insight whatsoever into their plans for how they will manage the backfield on Sunday in Seattle. Arizona's backfield has been a nightmare for fantasy managers to figure out recently, but Demercado provides some element of explosiveness and big-play ability that Bam Knight and Michael Carter don't offer. Knight has maintained the slight upper hand on snaps in recent weeks, while Carter has slid to the RB3 role. Demercado has the most juice as a receiver out of the backfield, which is an area that Seattle has struggled with this season, allowing the second-most receptions (48) to opposing running backs. It's tough to know for certain, but Knight and Demercado project to split most of the touches on Sunday, with Knight on early downs and Demercado on pass downs.

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Arizona Cardinals quarterback Jacoby Brissett is in line to make his fourth start of the season, with Kyler Murray (foot) placed on Injured Reserve and his future with the team being in question. Brissett has provided a jolt for the Cardinals' offense since becoming the starter in Week 6, completing 65.8% of his passes for 860 yards, six touchdowns, and one interception while adding 14 carries for 49 yards and another score on the ground. The 32-year-old has averaged 22.8 fantasy points and ranks as QB10 during that span. Brissett has elevated the offense with his ability to work on time and in structure, with Marvin Harrison Jr. recording a career high seven catches in their Week 9 win at the Dallas Cowboys and feeding star tight end Trey McBride targets in the red zone, with him scoring four touchdowns in Brissett's three starts. Brissett faces a tough matchup in Week 10, as they face the division-leading Seattle Seahawks, who allow just a 5.4 net yards per pass attempt this season, the seventh-best mark in the league.

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San Francisco 49ers quarterback Brock Purdy (toe) is getting a lot closer to returning, and the team is hopeful that he can start in Week 11 against the Arizona Cardinals, according to Jeremy Fowler of ESPN. The 49ers will decide before their matchup on Sunday against the Rams if Purdy will be active as the team's No. 2 quarterback behind Mac Jones, a promising sign in his recovery. Purdy came back in Week 4 against the Jaguars, but ultimately made the turf toe injury worse and has since missed five consecutive games. The 25-year-old hasn't registered a full practice since Week 4, but it looks like he is getting close to returning as San Francisco's QB1. Jones has filled in admirably in Purdy's absence, but he will move back to being the backup quarterback once Purdy is ready to go.

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New Orleans Saints tight end Juwan Johnson caught the only Saints touchdown in Week 9 against the Rams, finishing with three receptions for 31 yards on four targets. This marked his sixth game of the season with at least 50 receiving yards or a touchdown. The return of fellow tight ends Taysom Hill and Foster Moreau briefly lowered Johnson's stock, but he has bounced back with 13 receptions for 163 yards and a touchdown over his last three games. With Rashid Shaheed traded at the deadline and the Saints lacking depth at the receiver position, Johnson should be in line for an uptick in targets. He ranks as a borderline TE1/TE2 against the Panthers in Week 10, who allow the 13th-most PPR points to tight ends.

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Atlanta Falcons tight end Kyle Pitts Sr. is seeing consistent looks in this offense in 2025, averaging over six targets, five catches, and 47 yards per game this season. Unfortunately, it has yet to translate to touchdowns, as the 25-year-old has recorded just one score on the year. That could change this weekend, as Week 10 brings a matchupin Germany against the Colts. Indianapolishas allowed the fourth-most passing yards per game in the NFL over itslast three games (268.7) andhas allowed 24.5 points per game on the road(16.6 PPG at home). Not only that, they've yielded a touchdown pass to a tight end in four consecutive games now. With newly acquired CB Sauce Gardner set to cover Drake London or another receiver, it could open things up more for Pitts, so the 6-foot-6 tight end projects as a top 10 option at the position this week.

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New Orleans Saints wide receiver Chris Olave caught three of four targets for 57 yards in the Week 9 loss to the Rams. The four targets marked a season low after he entered the week ranked second in the league in targets while Spencer Rattler was under center. With rookie Tyler Shough now at the helm, the two will need to develop chemistry quickly, especially after the Saints traded away Rashid Shaheed, who led the team in targets during Shough's first start. Olave is averaging a career-low 10.2 yards per reception but a career-high 6.1 catches per game, showcasing his reliability as the clear No. 1 option in the passing game. His ceiling remains high, though quarterback uncertainty keeps him in the WR2 range for Week 10 against a tough Panthers defense that has allowed the sixth-fewest PPR points to wide receivers.

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New Orleans Saints running back Devin Neal logged three carries for 11 yards and caught his lone target for one yard in the Week 9 loss to the Rams. With Alvin Kamara officially questionable due to an ankle injury ahead of Week 10, Neal could be in line for additional work. The rookie was a sixth-round pick after an impressive career at Kansas, where he set program records with 4,343 rushing yards and 49 touchdowns. However, he's seen limited action in the NFL, totalling just six carries for 21 yards and four receptions for 12 yards. Even if he draws the start against the Panthers, Neal should remain on waivers in most formats, though he could hold deep-league appeal if Kamara is sidelined.

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Washington Commanders quarterback Jayden Daniels (elbow) could potentially return after three weeks, though the timeline could end up being a five to six-week period depending on when his evaluation after the bye week in Week 12, according to Jeremy Fowler of ESPN. Daniels did not suffer any ligament damage and won't need surgery on his injured left elbow, and will avoid being placed on Injured Reserve. It was a gruesome-looking injury for the second-year quarterback during Washington's Week 9 loss to the Seahawks, but it looks like Daniels avoided a significant season-ending injury and could be back for the team's Week 13 matchup against the Broncos following their bye week. Washington's record could play into the decision on when and if he returns, but if he is back to full health, fantasy managers can expect Daniels to suit up and play. Veteran Marcus Mariota will slide back in as the starter while Daniels is sidelined.

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