The Arizona Cardinals were blown out on the road 44-22 by the division-rival Seattle Seahawks in Week 10, but veteran quarterback Jacoby Brissett was able to rack up yardage and throw two more touchdowns for fantasy managers in two-QB leagues on Sunday. Brissett finished the day 22-for-44 passing for 258 yards, two touchdowns, and no interceptions while adding four carries for an additional 31 yards on the ground. The 32-year-old was sacked five times for a loss of 52 yards. Seattle went up 35-0 in the first half, so all of Brissett's fantasy production on Sunday was basically in garbage time. Brissett's 258 passing yards were actually his fewest in his four starts with Kyler Murray (foot) injured, but he's now thrown eight touchdowns and only one pick in his time as Arizona's starter. He'll be in play as a QB2 again in another divisional matchup in Week 11 against the San Francisco 49ers. With Murray now on Injured Reserve, Brissett is guaranteed to make at least three more starts.

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Seattle Seahawks wide receiver Jaxon Smith-Njigba got off to a hot start during Sunday's game against the Arizona Cardinals. Smith-Njigba scored a 43-yard touchdown on the opening drive. He took a shot to the head later in the first quarter and was taken out of the game to be evaluated for a concussion. Luckily, Smith-Njigba was fine and returned to continue doing damage to this defense. He finished his day with five receptions on six targets for 93 yards and a touchdown in the win. Smith-Njigba becomes the first player this season to reach 1,000 receiving yards. He'll look to keep the good times rolling against the Los Angeles Rams next weekend.

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Pittsburgh Steelers CB Darius Slay (concussion) left the Week 10 game against the Los Angeles Chargers in the first half to be evaluated for concussion. His return is questionable.

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Seattle Seahawks DL DeMarcus Lawrence finished with four tackles and 0.5 sacks, and he had two fumble recoveries for touchdowns in a 44-22 win over the Arizona Cardinals in Week 10.

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Los Angeles Rams running back Kyren Williams has seen a reduced role in the backfield this season. Despite that, Williams continues to find ways to succeed, which he did once again on Sunday. Williams rushed 14 times for 73 yards and scored two touchdowns in the win over the San Francisco 49ers. He has now scored three touchdowns over his last two games. The biggest downside is that Williams continues to split up the backfield duties with Blake Corum. The Rams might need to rely on Williams more heavily next weekend in what could be a high-scoring affair against the Seattle Seahawks.

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Los Angeles Rams QB Matthew Stafford completed 24-of-36 passes for 280 yards, four touchdowns and no interceptions in Week 10 against the San Francisco 49ers, while adding three runs for minus-3 yards. He is the first player in NFL history to throw four or more touchdown passes with no interceptions in three consecutive games.

Fantasy Spin: Stafford has 13 TD strikes in that three-game span, and he has multi-touchdown games in seven of his past eight outings. His last interception came back in Week 3 in Philadelphia, too. He has re-emerged as a bona fide QB1 in all fantasy leagues. Let's just hope his back continues to hold up, as he is crushing it right now.

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Detroit Lions wide receiver Jameson Williams got off to an extremely slow start to Sunday's game against the Washington Commanders. Williams entered halftime with only one reception for 19 yards. Fantasy managers thought they were getting a dud from Williams, but he turned it around in the second half. Williams finished his day with six receptions on seven targets for 119 yards and a touchdown in the blowout win. This is now back-to-back games in which Williams has found the end zone. He'll look to keep that streak alive against the Philadelphia Eagles next week.

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Tampa Bay Buccaneers WR Sterling Shepard posted three receptions for 20 yards on four targets in Week 10 against the New England Patriots.

Fantasy Spin: The veteran Shepard is well behind rookie Emeka Egbuka, TE Cade Otton and Tez Johnson for targets, but there is a role for the receiver still. He is worth a look as a WR5 in fantasy leagues of 12 or more teams as long as Mike Evans and Chris Godwin are both sidelined.

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Seattle Seahawks WR Cooper Kupp caught both of his targets for 74 yards in a 44-22 win over the Arizona Cardinals in Week 10.

Fantasy Spin: Kupp salvaged his stat line with a 67-yard reception, but he has now finished with two receptions or less in three straight games. With Jaxon Smith-Njigba emerging as a one of the premier receivers in the NFL, Kupp has slid into WR5 territory.

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San Francisco 49ers quarterback Mac Jones has been able to make the most of this starting opportunity while Brock Purdy (toe) is sidelined. On Sunday, Jones did everything he could to help his team win, but unfortunately it wasn't enough. He completed 33-of-39 passing attempts for 319 yards with three touchdowns and one interception in the loss to the Los Angeles Rams. Jones made some mistakes as well, but he also posted his third 300-plus yard passing game of the season. It's unclear if Purdy will be ready to start for the Week 11 matchup against the San Francisco 49ers. If not, Jones should be viewed as a streaming option for that one.

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Detroit Lions quarterback Jared Goff didn't seem to have any issues during Sunday's game against the Washington Commanders. This defense had absolutely no answers for Goff as he picked them apart all game. Goff completed 25-of-33 passing attempts for 320 yards with three touchdowns and zero interceptions in the win. The 31-year-old has now thrown for multiple touchdowns in five of his last six games. This marked only the second time this season that Goff has thrown for over 300 yards in a single game. He'll look to keep the fun times going against the Philadelphia Eagles next weekend.

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Arizona Cardinals tight end Trey McBride posted his best performance of the season during Sunday's game against the Seattle Seahawks. McBride carried a three-game touchdown-streak into this contest, which was in jeopardy until he scored mid-way through the third quarter. Overall, McBride finished with nine receptions on 15 targets for 127 yards and one score in the blowout loss. McBride has seen his fantasy value quickly rise with Jacoby Brissett under center. The Cardinals figure to ride with Brissett for the rest of the season, which is good news for McBride fantasy managers. He'll carry his now four-game touchdown-streak into the Week 11 matchup against the San Francisco 49ers.

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Seattle Seahawks QB Sam Darnold completed 10 of his 12 passes for 178 yards, a touchdown and an interception in a 44-22 win over the Arizona Cardinals in Week 10. He also lost a pair of fumbles.

Fantasy Spin: The Seahawks surged to a 35-0 lead and led 38-7 at halftime. As a result, Darnold didn't have to throw the ball much, leading to a rough stat line for fantasy purposes. Expect a more typical performance from Darnold in Week 11 when Seattle faces the Los Angeles Rams in a divisional battle.

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Los Angeles Rams quarterback Matthew Stafford completed 24 of his 36 pass attempts for 280 yards, four touchdowns, and zero interceptions during Sunday's Week 10 win over the San Francisco 49ers. The veteran quarterback continues to strengthen his MVP candidacy, playing turnover-free football while racking up passing touchdowns. He has now thrown for at least four touchdowns in each of his last three games, totaling 13 touchdowns and zero turnovers during that three-week span. He has a whopping 25 touchdowns and just two turnovers in 2025, keeping the Rams in the hunt for the top seed in the NFC. All the while, he has maintained QB1 value in fantasy football despite his lack of rushing upside. Managers should start him in all leagues ahead of next week's matchup against the Seattle Seahawks.

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Detroit Lions running back Jahmyr Gibbs had 15 carries for 142 rushing yards and two rushing touchdowns during Sunday's Week 10 win over the Washington Commanders. He also caught three of his four targets for an additional 30 receiving yards and one receiving touchdown. Just one week removed from a disappointing showing at home, Gibbs bounced back with a monstrous three-touchdown explosion on the road. This marked his largest fantasy points total of the 2025 season, vaulting him to the overall RB4 spot in PPR leagues. Managers should continue to deploy Gibbs as a high-end RB1 in fantasy football, including next week against the Philadelphia Eagles.

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Tampa Bay Buccaneers LB Lavonte David posted team bests with nine total stops and six solo tackles in Week 10 against the New England Patriots.

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Los Angeles Chargers running back Omarion Hampton (ankle) was not wearing a walking boot as he watched his teammates warm up ahead of Sunday's Week 10 contest against the Pittsburgh Steelers. The absence of a boot is a promising sign as Hampton inches closer to his return from injured reserve. The rookie has been sidelined since Week 5, leaving Kimani Vidal as the team's lead running back. Once Hampton is healthy enough to return, he should reclaim the every-down role that he occupied prior to his injury. Before he's activated, though, he'd need to be designated to return and log a few promising practice sessions. As soon as he gets back onto the field, he'll rank as a solid RB1 for fantasy football.

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San Francisco 49ers quarterback Brock Purdy (toe) will "have a chance" to play in next week's contest against the Arizona Cardinals, head coach Kyle Shanahan told the media. The 25-year-old has been sidelined for most of this season, playing just two of the Niners' 10 games so far. Mac Jones is playing above .500 in his absence, but he lost to the Rams on Sunday and now has six turnovers over his last four games. The return of Purdy should elevate the 49ers' offense while continuing to support strong fantasy outings from players like Jauan Jennings, George Kittle, and Christian McCaffrey. Meanwhile, Purdy himself should rank as a low-end QB1 in fantasy football.

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Arizona Cardinals QB Jacoby Brissett completed 22 of his 44 passes for 258 yards and two touchdowns and rushed four times for 31 yards in a 44-22 loss to the Seattle Seahawks in Week 10. He also lost a pair of fumbles that were returned for touchdowns.

Fantasy Spin: The Seahawks jumped out to a 35-0 lead, and Brissett threw the ball early and often as the Cardinals tried to dig out of the huge hole. Brissett has now thrown for more than 250 yards and two touchdowns in four straight games, and he looks like a solid QB2 option as long as he remains the starter.

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New England Patriots TE Hunter Henry ended up with just a single 9-yard reception on four targets in Week 10 against the Tampa Bay Buccaneers.

Fantasy Spin: Henry has shown TE1 fantasy ability at times, he also has been limited to just one catch and under 10 yards in two of his past three games. He has managed 33 or fewer yards in four of the past five games, too. Treat him more as a TE2 in fantasy leagues of 12 or more teams heading into Week 11 against the New York Jets on Thursday.

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