

| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Oct 28 1:16pm ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 1:16pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 1:16pm ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 1:16pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Oct 28 8:08pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Oct 28 8:08pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Oct 28 8:08pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 8:08pm ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 8:08pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:08pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 10:04pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Oct 28 10:04pm ET |
| Benched | QB | Spencer Rattler NO | Owner | Tue Oct 28 2:54pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 2:54pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Oct 28 2:54pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Oct 28 2:54pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Oct 28 2:54pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 2:54pm ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 2:54pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 2:54pm ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 10:40pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 10:40pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 10:40pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Oct 28 10:40pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 10:40pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 10:40pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 12:29pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 12:29pm ET |
| Started | RB | David Montgomery DET | Owner | Tue Oct 28 12:29pm ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Oct 28 12:29pm ET |