Gavin Sheets crushed a two-run homer in the first inning to spark a 24-hit attack as the San Diego Padres notched their largest margin of victory in franchise history, routing the slumping Colorado Rockies 21-0 on Saturday night in Denver.

Fernando Tatis Jr., Xander Bogaerts, Jake Cronenworth and Jason Heyward also homered. Jackson Merrill had four hits, and Elias Diaz and Luis Arraez had three hits apiece to help back Stephen Kolek (2-0), who tossed a five-hit shutout with seven strikeouts in his second major league start.

The Padres set a season high for runs and hits for the second straight night after Friday's 13-9 win in Denver on 16 hits, and its 24 hits tied a franchise record. Every position player except for reserve left fielder Brandon Lockridge (0 for 1 with a walk) had at least a hit on Saturday, and eight had more than one.

Colorado has dropped eight in a row, including five straight on its homestand that ends Sunday. The Rockies have been outscored 63-18 in the five games. Catcher Jacob Stallings pitched the final two innings and yielded one run on two hits with no walks and one strikeout.

Red Sox 10, Royals 1

Rafael Devers went 4-for-4 with three RBIs, Trevor Story hit a three-run homer and Carlos Narvaez added a two-run blast as visiting Boston snapped Kansas City's seven-game win streak.

It was the second four-hit game of the season for Devers and 15th of his career. Ceddanne Rafaela tripled, doubled and scored twice, Jarren Duran went 2-for-5 with an RBI and two runs for Boston. Garrett Crochet (4-2) picked up the win, limiting Kansas City to one run on seven hits over seven innings.

Bobby Witt Jr., who had two hits, doubled for the team's lone extra-base hit. Hunter Renfroe and Vinnie Pasquantino each added two hits for Kansas City, which lost for just the third time in its last 19 games. Cole Ragans (2-2) suffered the loss, allowing four runs on seven hits in five innings.

Athletics 11, Yankees 7

Shea Langeliers went 4-for-5 with a three-run homer and a two-run double and the host A's rallied to beat New York.

Luis Urias hit a solo homer and Brent Rooker added a three-run shot for the Athletics, who trailed 6-4 after Aaron Judge and Oswald Peraza homered in the Yankees' five-run sixth. It was Judge's second homer of the game -- he leads MLB with 14 -- but the Yankees had their three-game winning streak snapped.

Grant Holman (4-0) earned the win with 1 1/3 scoreless innings. Mason Miller recorded five outs -- four on strikeouts -- for his 11th save. Tyler Soderstrom had two hits and two RBIs for the Athletics, who scored a combined seven runs in the seventh and eighth innings to end a three-game skid.

Cubs 6, Mets 5

Cade Horton got a win with four innings in relief in his major league debut as Chicago made an early lead stand, hanging on for a victory over host New York.

Called up to replace injured Shota Imanaga (strained left hamstring), Horton (1-0) followed opener Brad Keller and allowed three runs on four hits. The 2022 first-round pick struck out five, walked none and threw 77 pitches.

Dansby Swanson homered and hit an RBI single and Miguel Amaya notched a two-run single as the Cubs halted their first three-game losing streak of the season. Brett Baty smacked a three-run blast and a two-run shot to provide all of the Mets' runs.

Reds 13, Astros 9

Elly De La Cruz drove in four runs during a 10-run first inning as visiting Cincinnati rode that breakout frame to a victory over Houston.

De La Cruz slugged a three-run home run and added a run-scoring groundout as the Reds pounced on Astros right-hander Lance McCullers Jr. (0-1). After De La Cruz smoked a line drive for his sixth home run, Tyler Stephenson laced an RBI single and Will Benson chased McCullers with an RBI double.

The Reds continued the onslaught against Logan VanWey, with Friedl adding an RBI single and McLain a bases-loaded walk before De La Cruz plated Connor Joe with a grounder. Gavin Lux capped the uprising with a two-run single that scored Friedl and McLain as Cincinnati sent 14 hitters to the plate.

Braves 3, Pirates 2 (11 innings)

Matt Olson homered and later scored the eventual winning run in the top of the 11th on a wild pitch to propel Atlanta past host Pittsburgh.

Olson, who hit his seventh home run of the season in the third, was the automatic runner at second in the 11th and moved to third on a groundout by Ozzie Albies. Olson was unable to score on Sean Murphy's groundout, but he came home when Pirates reliever Chase Shugart (1-3) fired a pitch low and inside.

Scott Blewett (2-0), who pitched a scoreless 10th, worked a perfect 11th despite the automatic runner Alexander Canario reaching third on a sacrifice bunt by Jared Triolo. Blewett struck out Liover Peguero looking and retired Tommy Pham on a groundout to end the game.

Diamondbacks 3, Dodgers 0

Corbin Burnes threw seven scoreless innings, Eugenio Suarez hit his 12th homer and Arizona shut out Los Angeles in Phoenix.

Burnes (2-1) gave up five singles, struck out five and walked two in his return after missing a start with shoulder inflammation. Suarez homered off Dustin May (1-3) in the sixth after Corbin Carroll tripled and scored on Ketel Marte's groundout in the third. Pavin Smith added three hits, including an RBI double.

Shohei Ohtani and Max Muncy singled and walked for the Dodgers, who were shut out for the third time this season. Freddie Freeman was 0-for-4 to end his 14-game hitting streak, during which he was 25-for-53 (.472).

Rangers 10, Tigers 3

Corey Seager hit two solo home runs and an RBI double as Texas ended a three-game losing streak with a win over host Detroit.

Seager's second multi-homer game this season led a five-homer barrage by Texas. Joc Pederson hit a two-run shot, while Josh Smith and Evan Carter supplied solo homers. Jacob deGrom (3-1) lasted five-plus innings, giving up two runs and five hits while striking out a season-high 10.

Kerry Carpenter had a single, triple and homer for Detroit. Riley Greene added a solo homer for the Tigers, who saw their five-game winning streak snapped. Detroit starter Jack Flaherty (1-5) gave up five runs and four hits -- all homers -- in three innings.

Phillies 7, Guardians 1

Bryce Harper belted a two-run homer and Ranger Suarez threw seven shutout innings as Philadelphia topped Cleveland.

Harper had a season-high three hits, and his 411-foot shot to center off reliever Joey Cantillo ignited a six-run eighth for the Phillies. Suarez (1-0) surrendered only three hits, all singles. Kyle Schwarber extended his on-base streak to 45, moving into a tie for the fourth-longest streak in team history.

The Guardians, who are 20-10 in a run that started April 8, scored their lone run in the ninth on a sacrifice fly by Carlos Santana, marking his 1,100th career RBI. Cleveland starter Tanner Bibee (3-3) was almost as effective as Suarez, giving up one run over seven innings.

Rays 3, Brewers 2

Travis Jankowski connected for a walk-off RBI single to lift Tampa Bay to a win over visiting Milwaukee.

Jankowski knocked the ball into left field off Milwaukee reliever Grant Anderson (1-2), scoring Kameron Misner, who had drawn a walk and stole second. Closer Pete Fairbanks (3-1) got out of a bases-loaded jam in his lone inning in the ninth to earn the win for the Rays, who claimed the series.

Jankowski also drove in a run with a sacrifice fly and Taylor Walls added an RBI double. The Brewers, who have lost three in a row, got solo homers from Jackson Chourio and Joey Ortiz but were limited to just four hits.

Twins 2, Giants 1

Trevor Larnach hit a two-run homer and Joe Ryan tossed six innings of one-run ball as Minnesota held on for its seventh straight win, beating San Francisco in Minneapolis.

Larnach and Harrison Bader doubled for the only other extra-base hits for the Twins. Ryan (3-2) gave up just two hits, struck out seven, walked none and threw 48 of 76 pitches for strikes.

Heliot Ramos went 3-for-3 with a double and a home run to lead the Giants, while Christian Koss singled for their only other hit. Right-hander Logan Webb (4-3) took the hard-luck loss, giving up two runs on five hits in seven innings. He struck out nine and walked one.

Cardinals 4, Nationals 2

Andre Pallante threw 7 1/3 strong innings, Lars Nootbaar drove in a pair of runs and St. Louis survived a shaky save from Ryan Helsley to beat host Washington.

Pallante (3-2) allowed two runs on five hits, with seven strikeouts and no walks as the Cardinals won their seventh consecutive game. St. Louis scored all of its runs in the second inning off Washington starter Trevor Williams (2-4), who allowed four runs in six innings, his longest start of the season.

Helsley retired the first two batters in the ninth but surrendered a single to Jose Tena then walked the next two batters. He secured his seventh save by getting CJ Abrams to fly out.

Blue Jays 6, Mariners 3

Addison Barger's run-scoring single broke a tie in the eighth inning as Toronto's victory snapped host Seattle's streak of having won nine straight series.

Bo Bichette doubled and homered for the Blue Jays, reliever Mason Fluharty (3-0) got the victory and Jeff Hoffman worked the ninth for his ninth save.

The Mariners' Rowdy Tellez went deep for the fourth time in five games this season against his former ballclub.

Angels 5, Orioles 2

Jack Kochanowicz threw 5 2/3 solid innings and Los Angeles beat Baltimore and even the series in Anaheim, Calif.

Jo Adell homered and the Angels scored in three of the first five innings on the way to snapping a two-game skid. Kochanowicz (2-5) worked 5 2/3 innings, allowing one run on four hits and four walks while striking out four.

The Orioles lost for the sixth time in their last seven games, with Ryan Mountcastle accounting for two of the team's six hits and Ramon Laureano providing a ninth-inning, pinch-hit home run. Kyle Gibson (0-2), making his third start of the season, took the loss, giving up five runs in four innings.

Marlins 3, White Sox 1

Eric Wagaman delivered a go-ahead, two-run triple with two outs in the eighth inning and Kyle Stowers homered to help visiting Miami defeat Chicago.

Marlins pitching limited the White Sox to four hits, including two from Lenyn Sosa. Jesus Tinoco worked a perfect ninth to pick up his third save. White Sox starter Shane Smith, a rookie right-hander, scattered four hits over six scoreless innings while matching a career high with seven strikeouts.

Chicago's Andrew Vaughn opened the scoring with a solo home run with two outs in the first, connecting against Marlins starter Edward Cabrera for his second homer in as many games.