Denver Broncos (3-2) vs. New York Jets (0-5)

Sunday, 9:30 a.m. ET (London)

FanDuel odds: Broncos -7, Total 43.5

Series Rewind: The Broncos have won eight of the past 12 meetings, including a 10-9 victory last season in Denver when Bo Nix passed for just 60 yards.

The Broncos feel the momentum percolating after taking down the reigning Super Bowl champion Philadelphia Eagles last week and do not want to experience a huge letdown. Denver is taking aim at its third consecutive victory and could be a factor in the AFC West since the Kansas City Chiefs aren't appearing so ferocious this season. Nix passed for 242 yards and one touchdown as the Broncos overcame a 14-point deficit to post a 21-17 win over the Eagles. Running back J.K. Dobbins has provided a big lift with 402 yards and four touchdowns. He ranks fifth in the NFL in rushing yardage and is tied for fourth in rushing scores. New York is not only the lone winless team in the NFL, but it is also the first team in league history to start 0-5 without forcing a single turnover. The Jets had some close calls, twice losing by two points. Being in London is a good thing in the eyes of New York coach Aaron Glenn as the scrutiny and noise is greatly diminished. New York is coming off a 37-22 home loss to the Dallas Cowboys. Justin Fields completed 32 of 46 passes for 283 yards and two touchdowns but was sacked five times.

New England Patriots (3-2) at New Orleans Saints (1-4)

Sunday, 1 p.m. ET

FanDuel odds: Patriots -3.5, Total 45.5

Series Rewind: The Saints outscored the Patriots 62-13 while winning the past two meetings (2021, 2023).

The Patriots are a much improved team under new coach Mike Vrabel and their next victory will equal their total in each of the past two seasons. New England delivered a big 23-20 road upset of the Buffalo Bills - the bullies of the AFC East - last week on the Sunday night stage. Second-year quarterback Drake Maye was just as good as Buffalo star Josh Allen. Maye completed 22 of 30 passes for 273 yards and calmly drove his team to a game-winning field goal. New England has been shaky on the ground and lost Antonio Gibson for the season with an ACL injury. The Saints are fresh off the first win of the Kellen Moore era as they scored the final 23 points while rallying to a 26-14 home win over the New York Giants. Takeaways fueled the win as Jordan Howden scored on an 86-yard fumble return and Kool-Aid McKinstry had two interceptions. Quarterback Spencer Rattler threw an 87-yard touchdown pass to Rashid Shaheed and won for the first time in 11 NFL starts. Rattler has thrown six touchdown passes and been intercepted just once this season. Defensive end Carl Granderson has 4.5 sacks and is on pace to surpass his career high of 8.5 in 2023.

Arizona Cardinals (2-3) at Indianapolis Colts (4-1)

Sunday, 1 p.m. ET

FanDuel odds: Colts -7.5, Total 46.5

Series Rewind: The Colts and Cardinals have been infrequent opponents, playing just three times since 2010. In 18 matchups, they've each won nine, with Indianapolis taking the last one 22-16 in 2021.

Daniel Jones keeps making the most of his new opportunity in Indianapolis. With last week's 40-6 rout -- the Colts' largest margin of victory since 2013 -- he's won more games in his first five with Indianapolis than the three wins he had in his final two seasons with the Giants. His 1,290 passing yards rank third in the league, and running back Jonathan Taylor continues to lead the league in rushing yards (480) and rushing touchdowns (6). The Cardinals, after a 2-0 start, have lost three straight games on field goals as time expired. Things may have gone from bad to worse as starting QB Kyler Murray did not practice Wednesday or Thursday due to a foot injury he played through in last week's loss to the Titans. If he's unable to play, Jacoby Brissett would get the start for an offense that is also down its top two running backs.

Cleveland Browns (1-4) at Pittsburgh Steelers (3-1)

Sunday, 1 p.m. ET

FanDuel odds: Steelers -5.5, Total 38.5

Series Rewind: The Steelers and Browns have played 147 times as long-time division foes. Pittsburgh leads the all-time series 82-64-1, and the two teams split last year's two games as well as the last 10 games between them.

It didn't take long this season for Pittsburgh to move into the driver's seat of the AFC South. The Steelers are the only team in the division above .500 and enter their first of two straight division matchups with a 1 1/2-game lead as they come out of a bye week. This despite the fact that Pittsburgh ranks 28th in total defense (382.5) and 29th in total offense (263.5). The Browns traded away Joe Flacco on Tuesday after Dillon Gabriel had a solid debut in a losing effort last week, throwing for 190 yards, two touchdowns and no turnovers. He's aided by rookie running back Quinshon Judkins -- Cleveland's only 100-yard rusher with 347 on the season -- and a defense that ranks second in yards per game allowed (247.8) and fifth in sacks (14).

Seattle Seahawks (3-2) at Jacksonville Jaguars (4-1)

Sunday, 1 p.m. ET

FanDuel odds: Jaguars -1.5, Total 47.5

Series Rewind: Another infrequent series that had been played every four years since 2001, the Seahawks lead the series over the Jaguars 6-3, winning the last matchup 31-7 in 2021.

Five games into the 2025 season, Jacksonville has matched last year's win total. It accomplished that with Monday's dramatic win over the Chiefs to improve to 4-1 for the first time since 2007. Trevor Lawrence scored the game-winning touchdown with 23 seconds left -- one of three on the night -- but also had two turnovers to bring his season total to seven (five picks, two fumbles). Although Seattle lost to Tampa Bay last week, it got an exceptional showing from Sam Darnold, who threw for 341 yards and four touchdowns. He ranks seventh in passing yards (1,246) and TD passes (seven). The Seahawks' third-ranked run defense (83 yards allowed per game) will test Jacksonville's fifth-ranked rushing offense (137 yards per game).

Los Angeles Chargers (3-2) at Miami Dolphins (1-4)

Sunday, 1 pm. ET

FanDuel odds: Chargers -4.5, Total 43.5

Series Rewind: The Dolphins have won four of the last six to take a 20-17 lead in the series. They last met in the 2023 opener when Tua Tagovailoa's late TD to Tyreek Hill gave Miami a 36-34 win.

It may not be Dan Fouts against Dan Marino, but this game is likely to be decided in the air. Passing is probably the best shot at victory for both squads, with the Chargers losing rookie rusher Omarion Hampton (ankle) to injured reserve and the Dolphins coming off a season-worst total of 19 rushing yards in a loss at Carolina. Miami could try to get speedy running back De'Von Achane rolling, while L.A. will turn to Hassan Haskins and Kimani Vidal to pick up the backfield slack. As for the signal-callers, the Chargers' Justin Herbert has a 13-2 INT-TD ratio in his last 10 road starts and the Dolphins' Tua Tagovailoa owns a 118.8 rating in his past seven home starts. The X-factor for Miami is formerly retired tight end Darren Waller, who has three TDs on eight catches in two games. Los Angeles has allowed TDs this year to tight ends Travis Kelce (Chiefs) and Theo Johnson (Giants).

Dallas Cowboys (2-2-1) at Carolina Panthers (2-3)

Sunday, 1 p.m. ET

FanDuel odds: Cowboys -3, Total 49.5

Series Rewind: The Cowboys have won the past three meetings and 12 of 15 all-time against the Panthers.

Cowboys QB Dak Prescott is second in the NFL with 1,356 passing yards and shares third place in TD passes with 10, a credit to his steady performance amidst rapid changes to personnel around him. Several offensive linemen have been banged up and No. 1 WR CeeDee Lamb has missed the past two games and most of the Week 3 win over the Bears with a high-ankle sprain. RB Javonte Williams helps balance the scheme with inside running to keep safeties honest and is third in the league with 447 rushing yards, ranking second in TDs with five. Dallas expects to see a motivated running back in the Carolina backfield in Rico Dowdle, who wasn't re-signed by the Cowboys after starting for the team last season. Dowdle posted a career-high 234 yards from scrimmage last week, the most gained by any player in the NFL this season, playing in Chuba Hubbard's spot. Hubbard was ruled out for a second consecutive game with a calf injury. Dallas put together its best defensive performance of the season last week at the Jets but is giving up more than 30 points per game. There are signs of life from the Panthers passing game. Bryce Young and rookie Tetairoa McMillan (24 catches, 351 yards) are showing a stronger rapport as fellow wideout Xavier Legette gets back in the groove. Legette returned to the lineup last week and caught his first TD of the season.

Los Angeles Rams (3-2) at Baltimore Ravens (1-4)

Sunday, 1 p.m. ET

FanDuel odds: Rams -7.5, Total 44.5

Series Rewind: The Ravens have taken five of the last six meetings, most recently a 37-31 thriller at home in Week 14 of 2023 on Tylan Wallace's 76-yard walk-off punt return in overtime.

Lamar Jackson's probable injury absence (hamstring) for a second consecutive week is the headliner, considering the Baltimore star is 24-5 vs. the NFC in his career with 61 total touchdowns (51 passing) and nine interceptions. With a bye next week allowing more time for No. 8 to heal, the Ravens will likely roll with longtime Dak Prescott understudy Cooper Rush and a huge helping of Derrick Henry. Henry hasn't rushed for more than 50 yards since Week 1 and is facing a Rams defense that has only allowed two rushing scores this season -- one on a Jalen Hurts "tush push." L.A.'s Matthew Stafford is not only healthy at age 37, he entered Week 6 ranked No. 1 in passing yards (1,503) and No. 2 in passing TDs (11). Top target Puka Nacua has been unstoppable with NFL highs in receptions (52) and yards (588). That's bad news for slumping Baltimore, especially with All-Pro cornerback Marlon Humphrey dealing with a calf injury.

Tennessee Titans (1-4) at Las Vegas Raiders (1-4)

Sunday, 4:05 p.m. ET

FanDuel odds: Raiders -3.5, Total 40.5

Series Rewind: The visiting team has won five of the past six meetings. Playing at home, Tennessee won the last meeting between the teams, 24-22 in 2022.

Cam Ward led the Titans to a stirring comeback and the franchise's first win of the season last week, becoming the first rookie QB to overcome an 18-point deficit and emerge victorious since 2019. Ward looked to WR Calvin Ridley (five receptions, 131 yards) for nearly half of his passing production (265 yards) in the win, which bumped coach Brian Callahan's career record to 4-18. The Raiders haven't won since Week 1. Las Vegas was whipped at Indianapolis 40-6 last week and turnovers have become a backbreaking issue with QB Geno Smith. He's thrown nine interceptions while working behind a makeshift offensive line due to injuries. Smith has been sacked 16 times. There's also the concern of not having TE Brock Bowers (knee). Ward threw for 193 yards in the furious fourth-quarter rally last week. More aggression from the passing game is a goal but on the road the Titans are more likely to lean on steady RB Tony Pollard to work ahead of the sticks.

San Francisco 49ers (4-1) at Tampa Bay Buccaneers (4-1)

Sunday, 4:25 p.m. ET

FanDuel odds: Buccaneers -3, Total 47.5

Series Rewind: San Francisco has won its past four meetings with Tampa Bay, including a 23-20 road victory last November.

Buccaneers quarterback Baker Mayfield is making himself an early-season MVP candidate by helping Tampa Bay squeeze out four victories by a combined nine points. Mayfield ranks fourth in the league with 1,283 passing yards and is tied for third with 10 touchdown passes. He has been intercepted just once in 172 attempts. He is coming off a dynamic performance in which he passed for a season-best 379 yards and two touchdowns in a 38-35 road victory over the Seattle Seahawks. Rookie WR Emeka Egbuka has been an immediate force and is the first player in NFL history with 25 catches, 400 yards (he has 445) and five touchdowns in his first five career games. He'll be vital with Chris Godwin (fibula) considered week-to-week with his latest injury. RB Bucky Irving is also out for the second game in a row. San Francisco quarterback Brock Purdy (toe) is expected to sit out for the fourth time in five games and Mac Jones (knee/oblique) will again attempt to fight through injuries. Jones passed for a season-high 342 yards to go with two touchdowns in a 26-23 overtime win against the Los Angeles Rams on Oct. 2. That win improved the 49ers to 3-0 on the road. With San Francisco shy on receivers, Kendrick Bourne had a career-high 142 yards while matching his career best of 10 catches against the Rams. Jones and Bourne previously played together for three seasons with the Patriots.

Cincinnati Bengals (2-3) at Green Bay Packers (2-1-1)

Sunday, 4:25 p.m. ET

FanDuel odds: Packers -14.5, Total 44.5

Series Rewind: The Packers have won two in a row in the series. The last meeting was a 2021 overtime decision that required Mason Crosby's field goal with two minutes left in the extra period. Davante Adams caught 11 passes for 206 yards for Green Bay.

Cincinnati brought in an old hand as its new QB, and 40-year-old Joe Flacco hopscotched from London to Cleveland to Cincinnati in a whirlwind 48-hour spell at the end of which he was declared the Bengals' starter for Week 6. Flacco was the starting quarterback of the Browns when the Packers lost in Cleveland, 13-10, last month and it's safe to say Packers coach Matt LaFleur knows plenty about him. He's described Flacco as the "most natural thrower of the football" he's ever seen, and Flacco played for the Jets under LaFleur's brother, Mike. That doesn't mean Flacco won't need some introductions before Sunday. He's not certain No. 1 WR Ja'Marr Chase (illness) can play, and the Bengals might shuffle things on the defensive side to stoke pass-rush pressure out of the front four. Coming out of their bye week, the Packers put up 40 points in their most recent game but scored a tie at Dallas. It was a step back for Green Bay's defense, which has been a juggernaut at home. QB Jordan Love has not thrown an interception in six consecutive home games. Injuries have forced constant changes on the Packers' offensive line, and RB Josh Jacobs is averaging only 3.3 yards per carry.

Detroit Lions (4-1) at Kansas City Chiefs (2-3)

Sunday, 8:20 p.m. ET

FanDuel odds: Chiefs -2.5, Total 52.5

Series Rewind: The Chiefs lead the all-time series 9-6, but Detroit won 21-20 at Kansas City the last time they faced off in 2023.

This matchup of last year's best team in the AFC and NFC during the regular season a year ago still has plenty of hype despite the Chiefs' slow start. With Monday's loss at Jacksonville, Kansas City already has more losses than it did in last year's regular season. While Patrick Mahomes appears to be back in form (588 passing yards, 5 passing TDs the last two games), the defense hasn't yet found the success of the last few seasons. That will really be tested against a Detroit offense that has scored 161 points during its current four-game winning streak since losing its season opener. Lions QB Jared Goff has thrown a league-best 12 touchdowns, half of which have gone to Amon-Ra St. Brown (407 yards, six TD catches).

Buffalo Bills (4-1) at Atlanta Falcons (2-2)

Monday, 7:15 p.m. ET

FanDuel odds: Bills -4.5, Total 49.5

Series Rewind: Buffalo has won the past two meetings after the Falcons won the previous four matchups.

Buffalo is no longer unbeaten after being outclassed 23-20 by the visiting New England Patriots in Week 5. The Bills will look to rebound against the Falcons, who are coming off a bye and surprisingly lead the NFL in total defense at 244 yards per game and pass defense (135.0). That means reigning MVP Josh Allen might face more of a challenge than expected as Buffalo looks to improve on the season low for points against the Patriots. Allen is enjoying another good season and has passed for 1,217 yards and nine touchdowns with two interceptions, and rushed for 212 yards and three TDs. James Cook is second in rushing with 450 yards but had just 49 with a long of 9 against New England. New defensive coordinator Jeff Ulbrich has been receiving raves for his work with Falcons while fixing up a unit that hasn't been sturdy in recent seasons. Rookie safety Xavier Watts has two of the team's three interceptions. Second-year quarterback Michael Penix Jr. can get better. He has three touchdown passes and three interceptions. Running back Bijan Robinson (314 rushing, 270 receiving) is an all-around force and 250 of his receiving yards have come after the catch.

Chicago Bears (2-2) at Washington Commanders (3-2)

Monday, 8:15 p.m. ET

FanDuel odds: Commanders -4.5, Total 49.5

Series Rewind: The Commanders beat the Bears 18-15 last season on a walk-off Hail Mary TD pass from Jayden Daniels to Noah Brown.

Commanders QB Jayden Daniels returned from a two-game absence due to a knee injury and guided Washington to a win over the Chargers last week. Daniels is going for a five-game streak without an interception and is 8-2 in 10 career starts at home. The D.C. area is home to Bears QB Caleb Williams, who grew up in the region and was selected one pick before Daniels went to Washington second overall in 2024. Daniels has the advantage of a consistent running game to balance the offense, a credit to seventh-round rookie Jacory Croskey-Merritt. He led team with career-high 150 yards from scrimmage against the Chargers and leads all NFL rookies with four rushing touchdowns. A groin injury hobbled Bears RB1 D'Andre Swift, who leads the Bears in rushing with 187 yards. Among the changes around Daniels since these teams last met are key contributors in veteran pass rusher Von Miller, wide receiver Deebo Samuel and left tackle Laremy Tunsil. Tunsil will help keep former Washington edge Montez Sweat out of the backfield.