Dallas Cowboys running back Miles Sanders (ankle, knee) has been moved to season-ending injured reserve, according to Patrick Walker of the Dallas Cowboys. Sanders was limited in practice on Wednesday before missing Thursday's practice, but now his season is over as he deals with multiple injuries to his ankle and knee. The 28-year-old served as the primary backup running back to Javonte Williams over the first four games of the season before missing Week 5. Rookie Jaydon Blue was active in his place and should step into a larger role now with Sanders out. Blue shouldn't be in lineups for Week 6, but he is an interesting speculative pickup ahead of Sunday's game against the Panthers.

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Dallas Cowboys wide receiver CeeDee Lamb (ankle) has officially been ruled out for the Week 6 game this Sunday against the Carolina Panthers after missing practice all week, according to Jon Machota of The Athletic. This will be the third straight game that Lamb misses after he suffered a high-ankle sprain in the Week 3 loss to the Chicago Bears. In addition to Lamb, KaVontae Turpin (foot) will miss a second straight game, leaving Dallas' receiving corps thin for another week. Lamb will need to get back on the practice field next week if he wants to have any chance of returning for a Week 7 divisional game versus the Washington Commanders. In the meantime, he needs to be firmly stashed in all fantasy leagues. George Pickens and tight end Jake Ferguson could both be in line for big days again this weekend with both Lamb and Turpin sidelined. Ryan Flournoy and Jalen Tolbert will battle for WR2 targets behind Pickens.

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Las Vegas Raiders tight end Brock Bowers (knee) has been ruled out for Sunday's game against the Titans, according to Adam Schefter of ESPN. Bowers is set to miss his second consecutive game while nursing a PCL/ bone bruise in his knee that he suffered back in Week 1 at New England. Head coach Pete Carroll emphasized the importance of "taking care of him" to ensure that when he returns, there are no setbacks. It was clear that Bowers was not right on the field, and his numbers reflected it, failing to exceed 50 yards in the three games following his 103-yard performance in Week 1. Third-year tight end Michael Mayer (head) is expected to return in Week 6 against Tennessee and could be relied on as a streamer at tight end for fantasy managers without Bowers.

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Washington Commanders wide receiver Terry McLaurin (quadriceps) did not practice again on Friday after also missing Thursday's practice. The Commanders did not officially practice on Friday, and the DNP tag for McLaurin is an estimate, but it is still not a good sign for his chances of suiting up on Monday night against the Bears. McLaurin was seen stretching with the team on Thursday during the part of practice that is open to the media, but ultimately worked on a side field with trainers as he continues to rehab. The reports would likely signal McLaurin missing his third straight game after initially injuring his quad in Washington's Week 3 win over the Raiders. Deebo Samuel Sr. will likely be the focal point of the passing attack again for Washington in Week 6, while rookie Jaylin Lane and second-year player Luke McCaffrey will have more opportunities.

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It's been a slow climb for Green Bay Packers wide receiver Matthew Golden to find fantasy relevance this season, but after the Packers' Week 5 bye, we could finally get some tangible results for Golden. The Packers host the Cincinnati Bengals in Week 6, and Golden is coming off his best week yet, with a season-high six targets, plus five receptions for 58 yards against the Cowboys in Week 4. Not only did he have his most productive week yet, but Golden is also starting to see the field regularly, with route shares of 82 percent and 72 percent in his last two games. In addition, Golden's first-read target shares have increased substantially, with just three first-read targets in the first two weeks of the season, but ramped up to nine in the last two contests. With the Packers seemingly building to a crescendo with Golden's week-by-week improvement, he's a big-time upside flex play for fantasy managers in Week 6.

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Green Bay Packers wide receiver Romeo Doubs is coming off by far his best game of the season in Week 4, with an awesome three-touchdown performance against the Dallas Cowboys. Doubs looks to keep that momentum going post-bye in Week 6 as the Packers host the Cincinnati Bengals. Week 4's final stat line against the Cowboys, aside from the touchdowns, was Doubs catching 6-of-8 targets for 58 yards. On the season, Doubs is tied with tight end Tucker Kraft with 19 targets and is second to Kraft in receptions and yards. Despite the raw totals, Doubs is averaging less than five targets, just over three receptions, and 45 yards in per-game statistics. With bye weeks here for fantasy, Doubs is a little bit of a reach for fantasy lineups, but in a good matchup against the Bengals in Week 6, Doubs is merely a low-end flex option for fantasy managers.

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Green Bay Packers wide receiver Dontayvion Wicks has a strong on-field role with the Packers, but he's a risky start this week despite a great matchup at home in Lambeau Field against the Cincinnati Bengals. In Week 4, Wicks ran a season-high 79 percent of routes per dropback and earned 77 percent of the team's snaps in Green Bay's 40-40 tie with the Dallas Cowboys. However, that didn't amount to much production as Wicks was targeted just four times and caught two passes for 19 yards on the evening. While we'd love for Wicks to be more involved on the production side of things, the lack of concentration in the Packers' passing game doesn't help the secondary pass-catchers get consistent volume. Leave Wicks either on your bench or on waivers when the Packers play the Bengals in Week 6.

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Arizona Cardinals quarterback Kyler Murray (foot) is listed as questionable for Sunday's game against the Colts, according to Tyler Drake of AZSports. Murray was able to get a limited practice in on Friday after missing Wednesday and Thursday, which will give him a chance to play on Sunday. He suffered the injury in the second half of Arizona's disappointing home loss to the Titans in Week 5, but he later returned and finished the game. Murray has been up and down this season for fantasy managers, but the Cardinals' offense would take a hit if he were to miss Sunday's game. Journeyman Jacoby Brissett would be in line to make the start in that case, but he's not an option to consider starting in Week 6.

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Green Bay Packers tight end Tucker Kraft has had a solid start to his second season as the full-time starting tight end for the Packers and looks to come off the team's Week 5 bye on the right foot when the Packers host the Cincinnati Bengals in Week 6. In Week 4, Kraft could only manage five targets with five receptions for 56 yards against the Cowboys in Green Bay's 40-40 tie. Kraft has been one of the best pass-catchers on the team this season, but even he is not immune to some of the things that plague the Packers' offense, like a lack of target concentration and pass volume concerns. Those factors bog down the upside case of the top Packers' pass-catchers and render the secondary pass-catchers irrelevant in most weeks. Kraft is a volatile boom-or-bust option with an inconsistent target-earning profile, but Week 6 represents a good matchup against the Bengals. Kraft is a fine start for fantasy purposes.

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Green Bay Packers running back Josh Jacobs looks to maintain his robust role and bring the production along as the Packers host the Cincinnati Bengals in Week 6. While the volume and workload for Jacobs are certainly strong, the per-rush output for Jacobs is certainly concerning. Jacobs only has 266 rushing yards this season on 80 carries for a 3.3 yards per carry mark. That's one of the lowest in the league among qualified running backs. He's buoyed that inefficiency with four rushing touchdowns and 10 receptions for 115 yards in the receiving game. If there's a game to get Jacobs' efficiency going, it's this week against the Bengals. Cincinnati has allowed 122.6 rushing yards to opposing rushers, which is tied for third-worst in the NFL. Additionally, they've also allowed the most fantasy points per game (26.8) to backfields this season. Lock in Jacobs as a top running back for fantasy this week in a great matchup.

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Pittsburgh Steelers wide receiver Calvin Austin III (shoulder) has been ruled out for Sunday's game against the Browns, according to Brooke Pryor of ESPN. Austin was unable to practice for the third straight day on Friday and will need more time to recover from his shoulder injury that he suffered in their Week 4 win over the Vikings. The 26-year-old has been productive when he's played this season, catching 10 of 17 targets for 139 yards and two touchdowns in four games. The Steelers' offense has struggled in the early part of the season, and puts D.K. Metcalf as the only wide receiver worth starting against Cleveland in Week 6.

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Green Bay Packers running back Emanuel Wilson should be a bit involved in the Packers' offense as the backup running back when Green Bay faces off against the Cincinnati Bengals in Week 6. In Week 4, before the team's bye last week, Wilson was more involved in the offense than usual, with eight carries for 44 yards. Wilson also factored in the passing game, catching 3-of-3 targets for 37 yards. Make no mistake, Wilson is firmly behind Jacobs in the pecking order of Packers' running backs, but Wilson continues to widen the gap between himself and Chris Brooks, who is barely involved in the Packers' normal offense. Wilson would get the first crack at meaningful touches in this strong Packers' offense if Jacobs were to go down, but you're not starting Wilson in fantasy football this week against the Bengals.

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Pittsburgh Steelers running back Jaylen Warren (knee) has now logged a full week of practice without limitation and carries no injury status into the team's Week 6 matchup with the Browns. Warren was a surprise inactive for the Steelers' Week 4 win over the Vikings in Dublin, but has since had a bye week and this full week of practice to get back on track. While Kenneth Gainwell had a week-winning performance in his stead, expect Warren to reclaim most of the team's early down and passing work, putting him right back into play as a safe-floor RB2/flex option, especially in PPR formats.

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New England Patriots rookie receiver Kyle Williams has yet to take 15 snaps in a game, and he hasn't seen a target since Week 3 against the Steelers, but his speed and quick release have shown up on film, and there's a chance his role could increase shortly. In Sunday night's win against the Bills, 90% of Williams' snaps came on passing plays, with the majority coming in the second half. Representing an element of speed that the Patriots' receivers room is otherwise lacking, he helped to create space for teammate Stefon Diggs on a night in which the veteran was targeted a season-high 12 times. With the Patriots traveling to New Orleans on Sunday, it's unlikely that Williams sees a breakout against a defense whose objective has been to keep everything in front of them, but should the rookie continue to do the things asked of him, he may see an increase in targets in the coming weeks.

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Green Bay Packers quarterback Jordan Love had an awesome game for fantasy managers who started him in Week 4 against Dallas, tossing three touchdown passes to wide receiver Romeo Doubs and piling up 337 passing yards. He'll look to continue that strong play in Week 6 when the Packers host the Cincinnati Bengals in Week 6. Love finished as fantasy's QB6 in Week 4, his first weekly finish as a top-ten quarterback since Week 6 of last season. It was also Love's first game with over 40 passing attempts since Week 4 of 2024. Passing volume isn't a regular thing for the Packers; it's more of an exception rather than the rule. If you're starting Love in Week 6, you're hoping the Bengals can score a bit, so the Packers get pushed to pass a bit more. Ultimately, Love is a viable starting quarterback for fantasy managers against a porous Bengals defense.

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Miami Dolphins quarterback Tua Tagovailoa (hip/thumb) carries no injury designation for the team's Week 6 matchup with the Chargers. Tagovailoa was a limited participant to start the week due to injuries to the thumb of his throwing hand as well as his hip, but has since logged two full practices and is a full go for Sunday. Through five weeks, Tagovailoa has averaged over 250 passing yards per game, throwing ten touchdowns to only four interceptions, and has shown an instant rapport with tight end Darren Waller over the past two weeks. In the Dolphins' first game without All-Pro wide receiver Tyreek Hill, he had arguably his best game of the year, but the Chargers' defense presents challenges that the Panthers could not in Week 5. Tagovailoa can be started in a pinch, but outside of superflex leagues, there should be better options available in most leagues.

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Los Angeles Chargers wide receiver Quentin Johnston (hamstring) is listed as questionable for Sunday's game against the Miami Dolphins due to a hamstring issue after being limited in practice all week. If he is active and fully healthy, Johnston has a good chance for a bounce-back game against a Miami secondary that allows the highest deep ball completion rate and the sixth-highest passer rating deep downfield, which fits his skill set well. Despite a season-low performance last week (4-40-0) that included a costly fumble, the former first-round pick still averages 75.4 receiving yards per game and has a 26.4% share of first reads. RotoBaller ranks him as WR14 this week. Managers should closely monitor his status this weekend and, even if he plays, temper expectations. Consider him a volatile high-end WR2 with a wide range of potential outcomes.

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Los Angeles Chargers quarterback Justin Herbert has a good chance to get the team back on track this week against the Miami Dolphins, who have one of the weakest defenses in the league heading into Sunday. Despite leading the team in rushing last week and being one of the top passers during the Chargers' early wins, Herbert's production has slowed due to injuries along the offensive line, taking 35 hits in the last three games. Critical penalties and the absence of Joe Alt (ankle) and Trey Pipkins (knee) continue to put pressure on Herbert. The Dolphins' defense ranks last in average rushing yards allowed. Still, the Chargers will be deploying backups Hassan Haskins and Kimani Vidal this week after Omarion Hampton (ankle) was placed on IR. The offense should lean more on the passing game and its proven weapons, but keep an eye on Quentin Johnston, who was limited all week with a hamstring injury and is questionable for Sunday. RotoBaller projects Herbert as the QB6 this week, making him a reliable high-end QB1 despite the offensive challenges around him.

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After missing Thursday's practice, Kansas City Chiefs second-year wide receiver Xavier Worthy (shoulder/ankle) was a full participant on Friday and carries no injury designation for Sunday night's clash with the Lions. Since returning from the shoulder injury that knocked him out of the season opener, Worthy has averaged 8.5 targets, 5.5 receptions, and 86 yards from scrimmage in the last two games, as Andy Reid and Matt Nagy have made an obvious effort to get him designed touches. In what should be the last game played without suspended receiver Rashee Rice, and what could turn into a primetime shootout, Worthy is a high upside WR2/flex play in Week 6.

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After logging two limited practices to start the week, New Orleans Saints tight end Juwan Johnson (ankle) was a full participant on Friday and is good to go for Sunday's matchup with the Patriots, according to head coach Kellen Moore. While Johnson has seen his target share and receptions drop dramatically over the last two weeks, the Patriots have been one of the league's worst teams at defending the tight end and have already ruled out starting safety Jaylinn Hawkins. Johnson has a chance to repeat some of his early-season success and could be readily available on waiver wires following two disappointing performances.

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