Indianapolis Colts quarterback Anthony Richardson Sr. has appeared in just two games so far this season, both times in mop-up duty at the end of blowout victories. The 23-year-old is firmly behind Daniel Jones on the quarterback depth chart in Indianapolis due to how well Jones has played through five games. In his first season with the Colts, Jones has completed 71.3% of his pass attempts for 1,290 yards and six touchdowns, adding three rushing touchdowns as well. Richardson Sr.'s dual-threat ability gives him major fantasy upside if he ever gets another chance to start, but for now, he remains an injury to Jones away from playing time.

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The Cincinnati Bengals acquired veteran quarterback Joe Flacco from the Cleveland Browns on Tuesday, and the team is going to "lean on him to stay alive for the playoffs," according to Ian Rapoport of NFL Network. Flacco is expected to take over for the struggling Jake Browning as the team's Joe Burrow (toe) replacement under center immediately in Week 6 against the Green Bay Packers. Flacco completed 58.1% of his passes for 815 yards, two touchdowns, and six interceptions in four games for Cleveland before getting benched. He should remain off the radar of fantasy managers in a difficult Week 6 matchup against Green Bay. Still, Flacco might have some season-long appeal in two-quarterback formats now that he's working with two elite wide receivers in Ja'Marr Chase and Tee Higgins with the Bengals.

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Denver Broncos running back J.K. Dobbins has "been fantastic," according to Broncos head coach Sean Payton. The 26-year-old is in his first year with the team and has gotten off to a fast start to the season, rushing for 402 yards and four touchdowns on 77 carries through five games. Dobbins does not offer much as a receiver (six total receptions), but he's been the clear lead rusher in a Broncos backfield that also features RJ Harvey and Tyler Badie. Health has always been a question mark for Dobbins, as he had played in just 22 games over his previous three seasons coming into 2025. However, if he stays healthy, it does not appear he's in any danger of losing his current role in Denver. Dobbins profiles as a must-start fantasy running back in Week 6 against the New York Jets.

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Houston Texans rookie wide receiver Jaylin Noel found the end zone for the first time in his NFL career during the team's dominant 44-10 win over the Baltimore Ravens in Week 5. The rookie caught two of three targets for 13 yards and a touchdown, marking his best performance of the season. Despite the great moment, Noel's fantasy relevance remains minimal. Through five games, he's caught just five passes and played only 26% of the team's offensive snaps, ranking sixth among Texans wide receivers. Both Noel and fellow rookie Jayden Higgins saw season-high snap counts in Week 5, largely due to the blowout nature of the game that allowed Houston to rest their starters. With Christian Kirk's return solidifying the top of the depth chart along with Nico Collins, Noel's playing time and target share are unlikely to increase in the near future. He's a developmental piece for the future, but for now, he remains off the fantasy radar.

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Kansas City Chiefs rookie wide receiver Jalen Royals missed the first two games of the 2025 season with a knee injury. He's been active in each of the team's last three games, but Royals has not yet been targeted by Chiefs quarterback Patrick Mahomes. The 22-year-old appears buried on Kansas City's wide receiver depth chart behind Xavier Worthy, Marquise Brown, Tyquan Thornton, and JuJu Smith-Schuster. Royals could fall down the depth chart even further in Week 7 when top Chiefs wideout Rashee Rice is eligible to return from suspension. Royals maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.

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Denver Broncos tight end Evan Engram has been off to a slow start in his first season under Sean Payton. Through four games, the veteran has caught 12 of 19 targets for 95 yards and a touchdown, ranking as the TE27 on a per-game basis. Despite optimism that Payton's system would unlock Engram's athleticism, he's yet to play more than 50% of the offensive snaps in any game this season. Even in Week 5, when Engram finally scored his first touchdown in Denver, his role remained limited. He played just 41% of the snaps, with Adam Trautman (40%) and Nate Adkins (37%) both involved in the rotation. The lack of a clear lead role in this tight end committee has capped Engram's production and fantasy appeal. Until his usage meaningfully increases or the depth chart thins out, Engram remains an afterthought in fantasy lineups and should stay on waivers in most leagues.

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San Francisco 49ers wide receiver Jauan Jennings could be in for a significant workload in Week 6, assuming he's healthy enough to play. Through three games this season, Jennings has caught nine of 19 targets for 129 yards and a touchdown, ranking as the WR40 on a per-game basis. The fifth-year wideout has battled through a string of injuries, including calf, ankle, shoulder, and rib injuries, that have limited his availability early in the year. Jennings returned to practice on Monday, which is a positive sign, especially with second-year receiver Ricky Pearsall (knee) trending in the opposite direction. If Pearsall is unable to suit up, Jennings would likely operate as the 49ers' WR1 heading into Week 6. Fantasy managers should keep a close eye on San Francisco's midweek injury reports, as Wednesday and Thursday's updates will be crucial in determining Jennings' and Pearsall's availability against the Tampa Bay Buccaneers.

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Kansas City Chiefs wide receiver Tyquan Thornton continues to emerge as one of the pleasant surprises of the 2025 season. Through five games, the former Patriots wideout has caught 13 of 25 targets for 272 yards and three touchdowns, ranking as the WR22 in half-PPR formats. Even with the recent return of second-year receiver Xavier Worthy, Thornton's production has held strong, totaling 101 yards and a touchdown over his last two contests. However, fantasy managers should tread carefully. The Chiefs' target competition is about to heat up, with Rashee Rice expected to return in Week 7 and Worthy likely to see an expanded role as he regains full health. That looming target competition could significantly cut into Thornton's target share. Thornton has flashed legitimate big-play ability and chemistry with Patrick Mahomes, but his long-term fantasy value is uncertain. He's best viewed as a strong sell-high candidate while his value remains high.

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Jacksonville Jaguars rookie wide receiver Travis Hunter could start to see more downfield opportunities after flashing big-play ability in Week 5's 31-28 win over the Kansas City Chiefs. The second-overall pick caught three passes for 64 yards, highlighted by a spectacular 44-yard jump-ball grab that showcased his elite athleticism and contested-catch skills. Plays like that offer a glimpse of what Hunter could become in Liam Coen's offense once his role expands. However, through five weeks, Hunter has yet to make a consistent fantasy impact. He's caught 16 of 24 targets for 182 yards and remains without a touchdown in his young career. His limited usage caps his fantasy upside for now, as he ranks 76th among receivers in snap share (60.3%) and 71st in route participation (69.7%). While his two-way ability continues to draw attention, Hunter's offensive workload remains too limited for reliable fantasy production. He's best viewed as a stash in deeper leagues, with breakout potential later in the season if his offensive role grows.

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New England Patriots running back Rhamondre Stevenson could be in line for an increased workload moving forward. Through five games, Stevenson has totaled 38 carries for 139 yards and two touchdowns, while adding 13 receptions for 154 yards through the air. With Antonio Gibson (knee) out for the season due to a torn ACL, both Stevenson and rookie TreVeyon Henderson should see expanded roles in the offense. While Henderson has been used sparingly to this point, Stevenson remains the most trusted option in New England's backfield. Despite leading the NFL in fumbles, the Patriots continue to rely on him in high-leverage situations, including the red zone. The team's faith in him makes Stevenson an intriguing buy-low candidate for fantasy managers. The Patriots face the New Orleans Saints in Week 6, a defense that has allowed the ninth-most PPR fantasy points to running backs this season. With more carries ahead and a favorable matchup, Stevenson profiles as a low-end RB2 in Week 6.

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ESPN senior NFL reporter Jeremy Fowler reported on Wednesday that Giants wide receiver Darius Slayton (hamstring) is not expected to play Thursday vs. the Eagles, per sources. Slayton suffered a hamstring injury in the Giants' Week 5 loss to the New Orleans Saints, and with the short turnaround time for Thursday night, it appears he will not be expected to play after missing practice both Monday and Tuesday. With Slayton not expected to play, Wan'Dale Robinson becomes the clear WR1 for the Giants in a game where they will be expected to throw quite a bit, as they are currently seven-point underdogs according to most sportsbooks. Jalin Hyatt, Beaux Collins, and Lil'Jordan Humphrey are the likely candidates to replace Slayton in the lineup, with Theo Johnson and Robinson becoming Jaxson Dart's go-to targets.

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New York Jets wide receiver Allen Lazard (personal) is out for the game in Week 6, as he didn't make the trip to England, where the Jets take on the Denver Broncos. Lazard is dealing with an unspecified personal issue, and Arian Smith and Tyler Johnson could see an uptick in snaps and targets as a result. Garrett Wilson and Mason Taylor remain quarterback Justin Fields' go-to targets in the pass game and should continue to be precisely that with Lazard out. Lazard has struggled to find his groove in 2025, seeing only six targets through four games, which have translated to only 24 yards and one touchdown. Fantasy managers still rostering Lazard should look elsewhere on the waiver wire and target a player trending upward.

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Baltimore Ravens quarterback Lamar Jackson's (hamstring) status for Week 6 is "in doubt," according to NFL insider Ian Rapoport. Jackson injured his hamstring in Week 4 against the Kansas City Chiefs and subsequently missed Week 5 at home against the Houston Texans. His status for Week 6 was initially questionable but is now reported as doubtful. Cooper Rush has stepped in as the team's quarterback and will presumably continue to take the snaps against the Los Angeles Rams in Week 6. With the Ravens having a Week 7 bye looming, the Ravens may want to play it safe with Jackson and allow him an extra two weeks of rest to ensure their superstar is fully healthy for the second half of the regular season. Fantasy managers should plan contingencies at the quarterback position sooner rather than later.

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Green Bay Packers running back Josh Jacobs takes on the Cincinnati Bengals on Sunday, and coming off a bye in Week 5, he should rank as a top-five running back for Week 6, as the Bengals give up the most running points to the running back position so far in 2025. The Packers' offensive line has been plagued by injuries, missing four starters throughout the first four weeks, which is likely the leading cause of his poor 3.33 YPC so far in 2025. Regardless, he is getting elite RB1 volume, with 80 carries, 10 receptions, and four touchdowns through four games played. Jacobs also does not have much competition in the backfield for touches, which makes him a high-end RB1, especially in good matchups like Week 6. Additionally, according to sportsbooks, the Packers are 14.5-point favorites, which should bode well for Jacobs to get some additional carries if they are playing from the lead.

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Dynasty | The Jaguars have placed tight end Brenton Strange on injured reserve. Dynasty Analysis: Strange is dealing with a hip injury that's now going to keep him out for at least a month. Poised for a breakout this year, Strange has posted a 20/204/0 line so far and been a bit of a disappointment. Hunter Long looks to be the beneficiary of his absence and could be a good pickup this week. Strange's ADP is likely to go down a touch with his rough start to 2025.

Los Angeles Chargers second-year running back out of Troy University, Kimani Vidal, is expected to step up in Week 6 after Omarion Hampton (ankle) was placed on injured reserve over the past week, and (Vidal) offers flex appeal as the Chargers travel to Miami to take on the Dolphins, who rank in the bottom five against opposing running backs in fantasy football. Vidal will likely be in a timeshare with fourth-year running back Hassan Haskins, who played at Michigan, where head coach Jim Harbaugh coached. Reports have yet to suggest that either running back will get the full workload, but based on past usage, Vidal is the younger, more pass-catching, third-down back, while Haskins should see carries on early downs. With how pass-happy the Chargers have been in 2025, throwing 62.58% of the time, in PPR leagues, Vidal should see four to six targets in the pass game, along with five to 10 carries, offering him some flex appeal in Week 6.

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Dynasty | Nyheim Hines has signed on with the Chargers practice squad. Dynasty Analysis: If this is the biggest move the Chargers make, it bodes well for the likes of Hassan Haskins and Kimani Vidal. It seemed inevitable the Chargers would sign someone after the losses of both Najee Harris and Omarion Hampton but Hines isn't much of a threat to this duo. Hines would be worth a roster spot should he be elevated to the active roster but he'd also likely clog a roster a bit as his ceiling is likely as a third down or receiving back. In the end, this is bigger news for Haskins and Vidal than Hines.

Los Angeles Rams wide receiver Puka Nacua has firmly established himself as a set-and-forget in fantasy football, which means that fantasy managers can confidently start him in all games without worrying about a potentially difficult matchup. Nacua has certainly shown that he can produce against any team, including the San Francisco 49ers, on whom he dropped 10 catches, 85 yards, and a touchdown last week. He remains the overall No. 1 receiver in fantasy football and is only trending upward as the season goes on. He's one of the steals of this year's fantasy drafts, as Nacua's production has league-winning potential even at his high ADP from the past summer.

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Los Angeles Rams wide receiver Davante Adams has continued to produce despite being second in the pecking order on his own team. The veteran receiver has 357 yards and three touchdowns this year, making him a high-end WR2 for week-by-week fantasy lineups. While Puka Nacua has earned the bulk of the attention in Los Angeles, Adams has made a significant impact, too, and his productivity so far should not be overlooked or taken for granted. The 32-year-old represents a safe, dependable WR2 or high-end flex option heading into Week 6 against the Baltimore Ravens.

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New England Patriots running back TreVeyon Henderson continues to make a push for more opportunities within the offense, but he hasn't seen much change in his fantasy value after five weeks of the NFL season. The Patriots continue to lean on Rhamondre Stevenson a little more than Henderson, even after the former lost three fumbles in three games. Stevenson touched the ball nine times on Sunday and was set up for two easy touchdowns despite averaging just two yards per carry. On the other hand, Henderson had eight touches and averaged four yards per carry, but still played less than half of the offensive snaps. He'll need to carve out a much larger snap share or start getting involved as a primary target for Drake Maye in the passing game before he becomes a worthwhile fantasy starter. In the meantime, he should be stashed on the bench.

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