ESPN's Adam Schefter reports that Arizona Cardinals wide receiver Marvin Harrison Jr. (appendix) underwent surgery for appendicitis and will be sidelined for "at least this week and possibly longer." It's a tough blow for the 23-year-old, who had recorded 10 catches for 129 yards and two touchdowns on 22 targets over the last two weeks. Harrison Jr. will now miss his team's Week 11 matchup against the San Francisco 49ers, and it appears there's no guarantee he'll be back in Week 12 to face the Jacksonville Jaguars. Without Harrison Jr. on the field, Arizona tight end Trey McBride could see an even larger target share. Additionally, Cardinals wideout Michael Wilson could be in line for significantly more looks from quarterback Jacoby Brissett. Wilson saw a season-high seven targets in Week 10 and may be in for another target spike in Week 11.

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In his team's first game following their Week 9 bye, Cleveland Browns wide receiver Jerry Jeudy hauled in six of 12 targets for 78 yards and a touchdown in Week 10 against the New York Jets. It's been an inconsistent season overall for the 26-year-old, who has recorded 28 catches for 335 yards and a score on 66 targets across nine games. However, Jeudy has now earned at least 12 targets in two out of his last four games played. If Week 10 was a sign of budding chemistry between Jeudy and Browns rookie quarterback Dillon Gabriel, the opportunity could be there for Jeudy to be a breakout player in fantasy over the second half of the season. Jeudy profiles as a low-end WR3/flex option heading into a Week 11 matchup against the Baltimore Ravens.

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NFL insider Ian Rapoport reported that the New York Giants have elevated Jameis Winston to the No. 2 quarterback on the depth chart and expect him to start Sunday in the event Jaxson Dart (concussion) doesn't clear the concussion protocol, per The Insiders. Winston was moved ahead of Russell Wilson, as interim coach Mike Kafka informed them. Additionally, ESPN's Adam Schefter reported that the Giants are expected to start quarterback Winston against the Green Bay Packers on Sunday, sources told Schefter and Jordan Raanan of ESPN on Wednesday. In a significant turn of events, both Schefter and Rapoport have reported that it's likely Winston gets the start against the Packers. He immediately raises the ceiling of the Giants' playmakers like Darius Slayton, Theo Johnson, and Wan'Dale Robinson, compared to what Russel Wilson can bring to the table at this point in his career. Winston is a bit of a wild card, but he will bring much more excitement to the team and Sunday's matchup. In his career, he has thrown for 24,225 yards, 154 touchdowns, and 111 interceptions. He can be started as a wild card in QB2 leagues once he is confirmed to be the starter.

Tampa Bay Buccaneers running back Bucky Irving (shoulder, foot) was spotted participating in the team's Wednesday morning walkthrough, according to Greg Auman of Fox Sports. Although he was never placed on Injured Reserve, Irving has missed five straight games for Tampa Bay due to shoulder and foot injuries. Irving's participation in a walkthrough does not necessarily mean he's on track to play in Week 11 against the Buffalo Bills, but it's at least a step in the right direction. Across the four games he's played in 2025, the 23-year-old has recorded 430 yards from scrimmage and two touchdowns on 90 total touches. Irving should eventually take over as the clear RB1 in Tampa Bay once he returns to the lineup. However, the team could re-integrate him slowly alongside running backs Rachaad White and Sean Tucker until Irving is fully healthy. Fantasy managers should check back throughout the week for updates on Irving's status heading into Sunday.

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New Orleans Saints quarterback Tyler Shough had a breakout performance in his first career win, completing 19 of 27 passes for 282 yards and two touchdowns in the 17-7 victory over the Panthers. Shough played with confidence throughout, connecting with Chris Olave on a 62-yard score in the second quarter to give the Saints the lead, and they never looked back. He later found Juwan Johnson for a 30-yard touchdown to seal the win. Shough had three completions over 25 yards, something the Saints had only achieved six times through Weeks 1-8 under Spencer Rattler. His deep-ball upside makes him a matchup-dependent streaming option, with Week 12 against the Falcons his next opportunity.

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Tampa Bay Buccaneers tight end Cade Otton had his best game of the 2025 season in Week 10, recording nine catches for 82 yards on 12 targets against the New England Patriots. After averaging 2.8 targets per game over the first four weeks of the season, Otton has averaged 7.4 targets per contest over his last five games. The 26-year-old appears to be one of the clear beneficiaries of injuries to Buccaneers wide receivers Mike Evans (collarbone) and Chris Godwin (leg). With Evans currently on Injured Reserve and Godwin trending towards missing his fifth straight game, Otton should continue to be a featured player in Tampa Bay's passing game. He profiles as a low-end starting fantasy tight end heading into a Week 11 matchup against the Buffalo Bills.

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Minnesota Vikings running back Aaron Jones Sr. has been limited to just five games played this season due to a hamstring injury that sidelined him from Week 3 to Week 7. However, the 30-year-old has been productive since returning to the lineup. Over his last two games, Jones Sr. has recorded 167 yards from scrimmage and a touchdown on 23 total touches. Perhaps most importantly, Jones Sr. appears to be re-emerging as Minnesota's lead back. In Week 10, Jones Sr. played 71% of the Vikings' offensive snaps, compared to just 25% for fellow running back Jordan Mason. Jones Sr. also saw a season-high six targets in Week 10. Heading into a favorable Week 11 matchup against the Chicago Bears, Jones Sr. profiles as a solid fantasy RB2.

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The Pittsburgh Steelers have activated quarterback Will Howard (hand) from Injured Reserve and waived running back Trey Sermon to make room for Howard on the 53-man roster. A sixth-round pick in the 2025 draft, Howard fractured his hand in training camp and was placed on Injured Reserve before the start of the regular season. In his senior season at Ohio State, Howard led the Buckeyes to a national championship and threw for 4,010 yards, 35 touchdowns, and 10 interceptions across 16 games. Howard appears likely to serve as the QB3 behind Aaron Rodgers and Mason Rudolph in Pittsburgh, at least for the time being. The 24-year-old has some deep-league dynasty appeal due to the uncertain long-term future of the quarterback position in Pittsburgh, but Howard is unlikely to factor in redraft fantasy leagues this season.

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Tampa Bay Buccaneers wide receiver Chris Godwin (fibula) is not expected to practice on Wednesday, according to the Tampa Bay Times' Rick Stroud. Godwin remains in "rehab mode," and early reports suggest he's trending toward a late-November or early-December return. The veteran wideout has appeared in just two games this season, contributing minimally as he continues to recover from the fractured fibula he suffered in 2024. In his absence, rookies Emeka Egbuka and Tez Johnson have stepped up as key targets in the passing game. The Buccaneers are expected to provide further updates on Godwin's progress later this month.

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New England Patriots rookie running back TreVeyon Henderson will look to build on his breakout performance heading into Week 11. Henderson dominated the backfield in Week 10, racking up 150 scrimmage yards and two touchdowns on 15 touches to help lead the Patriots past the Tampa Bay Buccaneers. Fantasy managers had been waiting for Henderson to get his opportunity, and he capitalized in a big way, playing 84% of the snaps after Rhamondre Stevenson (toe) was ruled out and Terrell Jennings (knee) exited early. With both backs still limited in practice ahead of Thursday night's matchup against the New York Jets, Henderson could be in line for a workhorse role and another big fantasy outing in Week 11.

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Tampa Bay Buccaneers running back Bucky Irving (foot/shoulder) is not expected to practice on Wednesday, according to the Tampa Bay Times' Rick Stroud. Irving remains in "rehab mode" and head coach Todd Bowles stated that he has no timetable for return. The second-year back has already missed the past four games and appears likely to miss additional time as he continues to recover from injuries suffered in Week 4. With Irving trending toward another absence in Week 11's matchup against the Buffalo Bills, Rachaad White and Sean Tucker are expected to continue sharing backfield duties against a struggling Buffalo run defense.

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Houston Texans quarterback C.J. Stroud is making progress through the NFL's concussion protocol ahead of Week 11. Stroud suffered the injury on a hard hit in Week 9 and was unable to clear protocol in time for last week's matchup. In his absence, backup Davis Mills led the Texans to one of their best offensive performances of the season, throwing for 312 yards and three touchdowns in a 36-29 win over the Jacksonville Jaguars. Stroud's status will be worth monitoring throughout the week as Houston prepares for a divisional showdown with the Tennessee Titans. If Stroud returns, he'll look to regain form and fend off any conversations of a quarterback controversy following Mills' strong outing.

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Arizona Cardinals running back Trey Benson (knee) is nearing a return to action in the coming weeks. Benson underwent arthroscopic knee surgery after Week 5 and was placed on injured reserve. The typical recovery timeline for a meniscus clean-up is four to six weeks, which puts him right on schedule entering Week 11. Before the injury, Benson logged 224 scrimmage yards on 41 touches across four games while mostly serving as the backup to James Conner. With Conner now out for the season, Benson is expected to step into the RB1 role once healthy. Fantasy managers should view him as a strong buy-low candidate who could make a significant impact down the stretch.

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Tampa Bay Buccaneers running back Sean Tucker will continue to see an expanded role in the coming weeks. Over his last two games, Tucker has logged 21 carries for 95 yards and a touchdown, helping fill the void left by second-year back Bucky Irving, who has missed the past four contests with foot and shoulder injuries. With no clear timetable for Irving's return, the Buccaneers will continue to rely on a tandem of Rachaad White and Tucker in the backfield. While White has handled the majority of the workload in Irving's absence, the rotation has shifted slightly toward a committee approach after head coach Todd Bowles expressed a desire to get Tucker more involved. Tucker is a name to monitor heading into Week 11 as the Bucs face a struggling Buffalo Bills run defense.

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The Jacksonville Jaguars have opened the practice window for tight end Brenton Strange, who has been sidelined since suffering a hip injury in Week 5's thrilling win over the Kansas City Chiefs. Head coach Liam Coen said Monday that Strange is designated to return in Week 11 and is "hopeful" he can suit up against the Los Angeles Chargers. Before the injury, Strange was off to a promising start, catching 20 of 24 targets for 204 yards through four and a half games of action. Fantasy managers should keep an eye on his practice participation this week, as Strange could be a sleeper to watch at the tight end position.

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New York Giants QB Jameis Winston will start in Week 11 if QB Jaxson Dart (concussion) can't go against the Green Bay Packers.

Fantasy Spin: Winston jumps over Russell Wilson on the depth chart but wouldn't be a wise choice in fantasy against a lethal Packers pass rush.

From TheHuddle

According to ESPN's Jeremy Fowler, the Baltimore Ravens could consider using the franchise tag on tight end Isaiah Likely. Likely is currently in the final year of his rookie contract, and would earn roughly $12 million in 2026 under the tag. After missing the start of the season with a broken foot, Likely has struggled to regain form, recording just 10 receptions for 103 yards through six games. The Ravens' tight end situation will be one to monitor next offseason, as veteran Mark Andrews is also approaching free agency. If Likely can rebound, he could emerge as one of the more intriguing tight end options on the 2026 market.

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ESPN's Matt Bowen and Jeremy Fowler wrote about their 2026 NFL free agency early top-25 ranking and predictions. Alec Pierce has been on fire the last few weeks and is averaging a league-best 20.9 yards per catch. He can take the top off the defence and lift safeties to create opportunities in open coverages underneath. In eight healthy games played this season, he has 585 receiving yards on 28 receptions and one touchdown. Teams that Fowler and Bowen have spoken to anticipate that Pierce will be looking at a ballpark of $20 million per year, or at least a number of that magnitude not being out of the question. He has the size and speed that make him a player who can be a valuable asset for teams in the market for a wide receiver. We will see how things play out for Pierce, but he is on a trajectory that is setting him up to be a winner in the offseason.

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ESPN's Matt Bowen and Jeremy Fowler wrote about their 2026 NFL free agency early top-25 ranking and predictions. According to what they are hearing, Breece Hall could secure a contract similar to Josh Jacobs, with a deal in the ballpark of a four-year, $48 million contract. Hall was very involved in speculation to be traded at the trade deadline, and the Jets stood firm on wanting a third-round pick in return for him, but they never got it. Hall is in his prime at 25 years old and brings a dual-threat element to the backfield. He has 174 receptions in his career, while averaging 92.0 total yards. He also has 82 rushes of 10 or more yards over three seasons, so he's a three-down back that can make big plays. Although we don't know which team he will be joining, this provides some insight into what the expected contract should be, barring any unforeseen developments over the next couple of months.

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ESPN reporter John Keim reports that Commanders head coach Dan Quinn mentioned that running back Chris Rodriguez Jr. (shoulder) will play Sunday. Rodriguez exited Week 10's contest against the Detroit Lions in the second half with an apparent shoulder injury and did not return. Before the Week 10 matchup, Rodriguez was chosen to be the team captain, and many reports heading into the week were suggesting that he might take over as the starter, and the way the first half played out, he was getting a majority of the work. However, we never got to see that fully play out due to his injury and his absence from the second half of the game. Jacory Croskey-Merritt and Jeremy McNichols remained involved and got all of the work in the second half. Still, given that neither Croskey-Merritt nor McNichols has run away with their opportunities as the starter, Rodriguez has a prime opportunity to do so in Week 11 against the Miami Dolphins, who are bottom-10 against opposing running backs on the season. Now that he's confirmed to play, Rodriguez should firmly be in the RB3/flex conversation heading into Sunday.

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