San Francisco 49ers quarterback Mac Jones completed 33 of his 49 pass attempts for 342 yards, two touchdowns, and zero interceptions during Thursday's win over the Los Angeles Rams. Jones made his third start of the season, getting the nod in place of Brock Purdy (toe). The former first-round pick has consistently impressed under center for San Francisco, amassing 905 passing yards, six touchdowns, and one interception through three games. It will be a shame to see his talent and fantasy production get sent back to the bench when Purdy returns, but at least the 49ers know they have an extremely capable backup who can dominate in a spot start. After all, he took down a division rival during overtime on national television Thursday. If Purdy misses Week 6 against the Buccaneers, Jones will rank as a high-end fantasy QB2. However, that game is 10 days away, leaving plenty of time for Purdy to get healthy.

From RotoBaller

Los Angeles Rams wide receiver Puka Nacua caught 10 of his 12 targets for 85 yards and one touchdown during Thursday's loss to the San Francisco 49ers. He had a relatively quiet first half with just three receptions before coming on strong during the second half as the Rams attempted to erase a significant deficit. Los Angeles did eventually tie the score before falling to the Niners in overtime. Nacua put his best foot forward with the game on the line, racking up double-digit receptions for the fourth time in five games this year. He continues to be the highest-scoring fantasy receiver this year and should be viewed as a high-end WR1 for Week 6 against the Ravens.

From RotoBaller

San Francisco 49ers running back Christian McCaffrey rushed for 57 yards on 22 carries during Thursday's Week 5 win over the Los Angeles Rams. He also caught eight of his nine targets for 82 receiving yards and a receiving touchdown. The superstar running back handled 30 total touches, continuing to prove that he's the only relevant member of the Niners' backfield for the time being. His efficiency on the ground was a little underwhelming, but that didn't stop him from dominating as a pass catcher, per usual. The 29-year-old has exceeded 22.5 fantasy points (PPR) in every game this season, ranking as the overall RB1 to this point. He should be started with full confidence against the Buccaneers in Week 6.

From RotoBaller

Los Angeles Rams quarterback Matthew Stafford completed 30 of his 47 pass attempts for 389 yards, three touchdowns, and zero interceptions during Thursday's Week 5 overtime loss to the San Francisco 49ers. The veteran signal caller was truly remarkable once again, as he has now thrown for 764 yards and six touchdowns over his last two games. He did take one sack and lose a fumble Thursday, but from a fantasy perspective, that's a very small blemish relative to his overall dominance throwing the football. Stafford now ranks fifth among quarterbacks in fantasy points per game, and he's currently first in total scoring, pending the results of the rest of Week 5. He should be deployed as a low-end QB1 against the Ravens in Week 6.

From RotoBaller

Los Angeles Rams running back Kyren Williams rushed for 65 yards on 14 carries during Thursday's overtime loss to the San Francisco 49ers in Week 5. He also converted 10 targets into eight catches, 66 yards, and two receiving touchdowns. It was a remarkable showing from the young running back as he delivered massive production as a receiver. After primarily being a ball carrier through his first three seasons, Williams has suddenly taken on a large role in the passing game with 13 catches and three receiving touchdowns over his last three contests. His dual-threat impact has allowed him to hold onto the lead back role over Blake Corum, who had 11 touches last Sunday but just one on Thursday night. While Williams' eight catches and two receiving touchdowns may not be sustainable going forward, managers should expect that he'll continue to make an impact on the ground and through the air. He's back in the low-end RB1 territory for Week 6 against an underwhelming Ravens defense.

From RotoBaller

Houston Texans running back Joe Mixon (foot/ankle) remains away from team facilities as he continues to recover from an offseason injury, and recent developments suggest a return this season is becoming less likely. The team has not indicated any expectation of seeing Mixon on the field in 2025, and rookie Woody Marks appears poised to take over as the lead back for the foreseeable future. Mixon made an immediate impact in his first season with Houston, rushing for 1,016 yards on 4.1 yards per carry and totaling 11 touchdowns. With his absence looking long-term, fantasy managers and Texans fans will need to pivot toward Marks and the team's committee approach in the backfield, leaving Mixon's once-promising fantasy potential on hold indefinitely.

From RotoBaller

Baltimore Ravens quarterback Lamar Jackson (hamstring) is likely sidelined until after the team's Week 7 bye, dealing a massive blow to an already struggling 1-3 squad. Jackson suffered the injury in last week's loss to Kansas City, forcing backup Cooper Rush into action, where he managed just 52 passing yards on 13 attempts. With their franchise QB out, Baltimore will need to lean heavily on Derrick Henry and the ground game to keep the offense afloat, while Zay Flowers and Mark Andrews figure to remain the focal points through the air. The matchup doesn't get any easier in Week 5, as the Ravens face a Houston Texans defense that ranks fifth in total yards allowed and seventh against the pass, setting up a difficult environment for Rush and the passing attack. Fantasy managers should temper expectations for Baltimore's offense until Jackson returns.

From RotoBaller

New Orleans Saints tight end Juwan Johnson (ankle) returned to practice in a limited capacity Thursday after sitting out Wednesday, leaving his status for Sunday's matchup with the Giants in question. Johnson has been the team's top receiving option through four games, leading the Saints with 204 yards. Should he be ruled out, Jack Stoll is expected to step in at tight end, though he's managed just three catches for 28 yards and one touchdown this season. A Johnson absence would likely push more targets toward wideouts Rashid Shaheed and Brandin Cooks, as quarterback Spencer Rattler may be forced to lean on his playmakers in what could be a fast-paced contest against an improving Giants offense. Fantasy managers should monitor practice reports closely, as Johnson's availability could significantly impact New Orleans' passing game.

From RotoBaller

San Francisco 49ers TE George Kittle (hamstring) has had no setbacks in his recovery and has a 'real chance' to play against the Tampa Bay Buccaneers in Week 6, according to Ian Rapoport of NFL Network.

Fantasy Spin: Kittle has been sidelined since suffering the injury in the season opener, but he will immediately join the TE1 ranks whenever he returns.

From TheHuddle

Tampa Bay Buccaneers WR Sterling Shepard (foot) was a full participant in practice Thursday, Oct. 2.

Fantasy Spin: On the heels of a solid Week 3 showing, Shepard had his worst performance of the season in Week 4. The two-catch, 14-yard outing coincided with the return of Chris Godwin, and even with Mike Evans sidelined, Shepard figures to be a distant No. 3 option behind Godwin and Emeka Egbuka. He doesn't need to be rostered.

From TheHuddle

Tampa Bay Buccaneers WR Chris Godwin (ankle) was a full participant in practice Thursday, Oct. 2.

Fantasy Spin: Godwin made his season debut in Week 4, and while he finished with just three catches, he was targeted 10 times. He is likely still rounding into form as he returns from a major ankle injury, but with Mike Evans sidelined, Godwin should have a heavy workload whether he is ready or not. Consider him a volume-based WR3 in Week 5.

From TheHuddle

Tampa Bay Buccaneers CB Jamel Dean (hip), WR Mike Evans (hamstring), RB Bucky Irving (foot, shoulder), S Christian Izien (quadriceps) and CB Benjamin Morrison (hamstring) did not participate in practice Thursday, Oct. 2. LB Lavonte David (knee) and S Tyreke Smith (ankle) were limited during the session. WR Chris Godwin (ankle), OT Charlie Heck (knee), CB Zyon McCollum (thumb), QB Baker Mayfield (biceps, knee), WR Sterling Shepard (foot), DT Greg Gaines (pectoral), DE Logan Hall (groin), LB Haason Reddick (neck) and OT Tristan Wirfs (knee) were full participants.

From TheHuddle

Las Vegas Raiders tight end Brock Bowers (knee) was downgraded to a DNP in practice on Thursday after he put in a limited session to begin the week on Wednesday, according to Anthony Galaviz of The Fresno Bee. It remains to be seen if Bowers actually had a setback with his left knee, which he initially injured in Week 1, or if the Raiders are just giving him some extra rest before Week 5 versus the Indianapolis Colts. Despite injuring his knee in the season opener, Bowers has played in all four games this year. However, since going over 100 yards receiving in Week 1, the second-year TE hasn't cleared 47 yards, and he hasn't found the end zone yet, either. Bowers might need a full practice on Friday to avoid a questionable tag going into Sunday's game at Lucas Oil Stadium, but if he's active, he's a must-start in fantasy despite his slow start.

From RotoBaller

Kansas City Chiefs CB Kristian Fulton (ankle) was limited during practice Thursday, Oct. 2. WR Hollywood Brown (ankle), DE Mike Danna (quadriceps), QB Patrick Mahomes (groin), DE Charles Omenihu (ankle), WR JuJu Smith-Schuster (knee), OT Jawaan Taylor (knee), LS James Winchester (hamstring) and WR Xavier Worthy (shoulder) fully participated in practice.

From TheHuddle

Seattle Seahawks OT Joshua Jones (ankle), DE DeMarcus Lawrence (quadriceps), S Julian Love (hamstring) and CB Devon Witherspoon (knee) did not participate in practice Thursday, Oct. 2. S Nick Emmanwori (ankle) and WR Cody White (shoulder) fully participated in practice.

From TheHuddle

Kansas City Chiefs QB Patrick Mahomes (groin) fully participated in practice Thursday, Oct. 2.

Fantasy Spin: Mahomes is coming off his best game of the season when he threw four touchdowns. He has all of his receivers available again and will be a starting option in all fantasy leagues.

From TheHuddle

Kansas City Chiefs WR JuJu Smith-Schuster (knee) fully participated in practice Thursday, Oct. 2.

Fantasy Spin: Smith-Schuster was able to find the end zone last week and was targeted a season-high six targets during the game. He will likely see a handful of targets again this week and could be a possible flex option in some deeper leagues.

From TheHuddle

Kansas City Chiefs quarterback Patrick Mahomes (groin) finds himself on the Week 5 injury report, but he was able to practice in full on Thursday. Mahomes is a little banged up, but since he's practicing in full for the first practice of the week, he shouldn't have any issues playing on Monday night against the 3-1 Jacksonville Jaguars to close out Week 5 action. In the first couple of weeks, Mahomes played through a wrist injury, but this is the first time in 2025 he's been listed with a groin injury. It's worth watching, but it shouldn't sway fantasy managers to bench him in Week 5 against the Jags. However, it's worth noting that Mahomes hasn't run much the last two weeks after going for over 100 yards on the ground and two touchdowns in Weeks 1 and 2. The Jags have been a top-10 matchup for opposing QBs so far in terms of fantasy points, and KC's offense is much more dynamic now that receiver Xavier Worthy is back from his shoulder injury.

From RotoBaller

San Francisco 49ers quarterback Brock Purdy (toe) suffered a setback with his turf-toe injury in the Week 4 loss to the Jacksonville Jaguars on Sunday and is now considered week-to-week, according to Ian Rapoport of NFL Network. Purdy was ruled out for the Thursday night divisional clash against the Los Angeles Rams to start Week 5, and he could miss additional games beyond Thursday night. The 25-year-old suffered turf toe in the regular-season opener, which caused him to miss Weeks 2 and 3. He threw for over 300 yards with two touchdowns and two interceptions in his return against Jacksonville, but now he's injured again and could miss more than one game. Backup Mac Jones will make his third start of the year on Thursday night in a bad matchup against L.A. without the team's top two wideouts in Jauan Jennings (ankle, ribs) and Ricky Pearsall (knee).

From RotoBaller

Los Angeles chargers WR Keenan Allen (non-injury) fully participated in practice Thursday, Oct. 2.

Fantasy Spin: Allen has been an important part of the passing game since returning to the Chargers and has been one of their top receivers over the first four games. He will see a good amount of targets again this week and can be a No. 2 receiver in fantasy leagues.

From TheHuddle